| Project/Area Number |
26861396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kusaba Yuki 熊本大学, 医学部附属病院, 医員 (70648592)
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| Co-Investigator(Renkei-kenkyūsha) |
MINODA Ryosei 熊本大学, 大学院生命科学研究部, 准教授 (30284772)
YAMADA Takao 熊本大学, 医学部付属病院, 医員 (90573593)
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| Research Collaborator |
TAKEDA Hiroki 熊本大学, 大学院耳鼻咽喉科・頭頸部外科学, 大学院生
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Tis21 / 聴覚 / Tis21遺伝子 / 内耳発生 / 内耳 / ラセン神経節 / 発生 |
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| Outline of Final Research Achievements |
We purchased Tis21 deficient mice from Jackson Laboratory ( the United States ) , underwent immunostaining and in situ hybridization, which examined the expression of Tis21 protein in embryonic inner ear . Morphological assessment of Tis21 deficient mice in the future ( cochlea form , the number of cochlear hair cells , spiral ganglion cell numbers , etc.) carried out , which is scheduled to be examined pathology of dysfunction . In addition , with respect to the context of the gene , such as Ngn1, NeuroD, Atoh1 and are involved in inner ear development , it is expected to examine using, for example, immunostaining.
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