| Project/Area Number |
26861397
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
NOMI NOZOMI 大分大学, 医学部, 助教 (40468020)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 頭頸部癌 / 腫瘍免疫 / ワクチン / がん微小環境 / 生体内ワクチン |
|---|
| Outline of Final Research Achievements |
Weaning the immunosuppression in tumor microenvioroment might be a new therapeutic target in cancer therapy, and we focused MFG-E8 for a in this study. We revealed following; 1) MFG-E8 expressed in head and neck cancer and there was significantly association between the expressions of MFG-E8 and T stage and survival rate, 2) MFG-E8 was released by granular form in head and neck cancer cell lines, however, 3) the expression of MEG-E8 did not correlate the sensitivity of anticancer drug. Therefore, MFG-E8 might not affect directly anti-apoptotic effect in head and neck cancer cells but suppress the local immunity in tumor environment.
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