| Project/Area Number |
26861402
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Tani Akiko 福島県立医科大学, 医学部, その他 (30554430)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Yasuhiro 福島県立医科大学, 医学部, 講師 (70363760)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 気管粘膜再生 / ビトリゲル / 線維芽細胞増殖因子 / 気管狭窄症 / 移植再生医療 / 気管再建 |
|---|
| Outline of Final Research Achievements |
The effectiveness of our scaffold with application of basic fibroblast growth factor(b-fGF) was investigated. Three types of scaffold were made: (A)no b-FGF, (B)10ng b-FGF, (C)100ng b-FGF. At7,14 and 28 days after implantation over tracheal defect, the trachea were removed and histologically evaluated.
High concentration of b-FGF promoted regenration of tracheal mucosa. Our research affords a feasible approach for accelerating the regeneration of the intraluminal surface and subepithelial layer of trachea.
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