Development of a novel artificial trachea using autologous chondrocytes and fibroblasts

• Project/Area Number: 26861403
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: Nomoto Mika 福島県立医科大学, 医学部, 講師 (50554416)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 再生医療 / 人工気管 / 軟骨細胞 / 線維芽細胞 / 気管再生

Outline of Final Research Achievements

In our previous study, tracheal regeneration was successfully achieved by using bio-engineered trachea with chondrocytes. Otherwise, delay of epithelization on the inner lumen of bio-engineered trachea was observed. Delay of epithelization may cause some problems including infection or tracheal stenosis.
The purpose of this was to develop a novel hybrid bio-engineered trachea with chondrocyte and fibroblasts, and to verify the effects of the trachea. As a result, cartilaginous regeneration was suppreded.