| Project/Area Number |
26861408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 頭頸部癌 / 肺転移 / IRF / インターフェロン調節因子 / 頭頸部扁平上皮癌 / 遠隔転移 |
|---|
| Outline of Final Research Achievements |
This study evaluated the correlations the invasion ability and the migration ability and IRF in head and neck squamous cell carcionoma cell lines. siRNA knockdown of IRF1, 2, 6 and over expression of IRF1, 2, 6 with IRFs vector in metastatic HNSCC cells did not suppress tumor invasion and migration. But, over expression of IRF1, 2, 6 with IRFs vector in metastatic HNSCC cells promote cell proliferation.
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