tinnitus in aging model mice

• Project/Area Number: 26861414
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: Oishi Naoki 慶應義塾大学, 医学部(信濃町), 講師 (10348740)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 耳鳴 / 加齢 / 加齢性難聴 / 驚愕反射

Outline of Final Research Achievements

Tinnitus in aging model mice was evaluated by gap detection test (GDT). Tinnitus accompanied by presbycusis was accessed prospectively and individually in CBA/J mice.
The hearing level and GDT were measured periodically from the age of 9 months to 20 months. The hearing level deteriorated according to their age and tinnitus at 24 kHz was detected by GDT at the age of 20 months.
These results are expected to lead to the finding of therapy on tinnitus followed by chronic hearing loss such as aging.