| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Rhinosinusitis is a common disease, but it is a disease that is often improved by administration of penicillin antibiotics or macrolide antibiotics in general. Especially in Japan, it is often improved by administering a small amount of macrolide antibacterial drug for a long period to chronic rhinosinusitis. On the other hand, there are cases where improvement is not achieved by such a treatment method, and these cases are often referred to as refractory. Especially it has been said that eosinophilic sinusitis, which became difficulty designation, has involvement of staphylococci.
Therefore, we carried out a study to see if the pathological condition exerting macrolide tolerance-induced morphological change plays a role in refractory.
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