| Project/Area Number |
26861426
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
OKAMOTO Hidehiko 生理学研究所, システム脳科学研究領域, 准教授 (30588512)
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| Research Collaborator |
KAKIGI Ryusuke 生理学研究所, システム脳科学研究領域, 教授 (10145196)
TAKESHIMA Yasuyuki 生理学研究所, システム脳科学研究領域, 技術職員
FUKUSHIMA Munehisa 関西ろうさい病院, 耳鼻咽喉科・頭頸部外科, 副部長
SEKIYA Kenichi 名古屋市立大学, 医学系研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ヒト / 突発性難聴 / 耳鳴り / リハビリテーション / 音楽 / 聴覚 / 可塑性 / 脳磁図 / 耳鳴 / 難聴 / 脳 / ニューロイメージング / イメージング |
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| Outline of Final Research Achievements |
Sudden sensorineural hearing loss is characterized by acute, idiopathic hearing deterioration. We developed and evaluated "constraint-induced sound therapy (CIST)", which is characterized by the plugging of the intact ear and the extensive stimulation of the affected ear with music. The patients who received the CIST showed significantly better hearing recovery compared to those who had only received corticosteroid treatments. Additionally, the brain activity obtained in a subgroup of patients suggested that the CIST could have prevented maladaptive auditory cortex reorganization.
Moreover, we non-invasively investigated the neural activity of unilateral tinnitus patients. The results obtained support the hypothesis that pathological alterations in inhibitory neural networks play an important role in the perception of subjective tinnitus.
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