New regulating factor of retinal circulation and establishment of treatment of diabetic retinopathy

• Project/Area Number: 26861428
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Asahikawa Medical College
• Principal Investigator: OMAE Tsuneaki 旭川医科大学, 医学部, 助教 (30451470)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 網膜循環

Outline of Final Research Achievements

In vivo and in vitro, we did not show that aldosterone, a potent vasoconstrictor, elicited constriction of retinal arterioles. Furthermore, there are no significant relationship between retinal parameter and serum aldosterone concentration in patients with type 2 diabetes.

Research Products

• [Journal Article] Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes. (2016)
  • Author(s): Tsuneaki Omae Taiji Nagaoka Akitoshi Yoshida
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57 Issue: 3 Pages: 1345-51
  • DOI: 10.1167/iovs.15-18813
  • NAID: 120006346197
  • Peer Reviewed / Open Access
• [Journal Article] Relationship Between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus. (2015)
  • Author(s): Tsuneaki Omae Taiji Nagaoka Akitoshi Yoshida
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 56 Issue: 6 Pages: 4143-4149
  • DOI: 10.1167/iovs.15-16447
  • Peer Reviewed
• [Journal Article] Role of Ca2+-Dependent and Ca2+-Sensitive Mechanisms in Sphingosine 1-Phosphate-Induced Constriction of Isolated Porcine Retinal Arterioles in Vitro. (2014)
  • Author(s): 2. Kamiya T, Nagaoka T*, Omae T, Yoshioka T, Ono S, Tanano I, Yoshida A.
  • Journal Title: Exp Eye Res Volume: 121: Pages: 94-101
  • DOI: 10.1016/j.exer.2014.01.011
  • NAID: 120006517759
  • Peer Reviewed
• [Journal Article] Beraprost sodium, a stable prostacyclin analogue, elicits dilation of isolated porcine retinal arterioles: roles of eNOS and potassium channels. (2014)
  • Author(s): Ono S, Nagaoka T, Omae T, Tanano I, Kamiya T, Otani S, Ishibazawa A, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Issue: 9 Pages: 5752-5759
  • DOI: 10.1167/iovs.14-14902
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 2型糖尿病患者における血清アディポネクチン濃度と網膜循環動態との関連 (2014)
  • Author(s): 大前 恒明ほか
  • Organizer: 第68回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] Retinal reperfusion following panretinal photocoagulation for diabetic retinopathy (2014)
  • Author(s): 大前 恒明ほか
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Orlando
  • Year and Date: 2014-05-04 – 2014-05-07
• [Presentation] 増殖糖尿病網膜症における無灌流量領域の汎網膜光凝固術後の再灌流の検討 (2014)
  • Author(s): 大前 恒明ほか
  • Organizer: 第118回日本眼科学会総会 (WOC 2014, APAO 2014 合同開催)
  • Place of Presentation: 東京
  • Year and Date: 2014-04-02 – 2014-04-06