Gene therapy using microorganism derived ion channel for retinal degeneration
| Project/Area Number |
26861433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 眼生理学 / 視細胞保護 / アデノ随伴ウイルスベクター / アデノ随伴ウイルスベクタ- / クロライドチャネル |
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| Outline of Final Research Achievements |
The aim of this study is to rescue the retina from the oxidative stress by using microbial ion channels. We develop the plasmid vectors including various types of microbial ion channel genes and established the constitutively those gene-expressing cell lines. We tested the protective effect on the glutamate toxicity in those cells. We could observe the protective effect in constitutively expressed cation channel gene but not chloride channel genes in the cells.
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Report
(3 results)
Research Products
(21 results)
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[Presentation] VISUAL PROPERTIES OF RCS RATS TRANSDUCED WITH2014
Author(s)
Sugano E, Tabata K, Takahashi M, Murayama N, Nishiyama F, Saito T, Tamai M, Tomita H
Organizer
International Society for Eye Research
Place of Presentation
Hyatt Regency, San Francisco (San Francisco, U.S)
Year and Date
2014-07-20 – 2014-07-24
Related Report
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