Neuroprotective treatment of glaucoma
| Project/Area Number |
26861434
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 緑内障 / 酸化ストレス / 網膜神経節細胞死 / 網膜神経節細胞 |
|---|
| Outline of Final Research Achievements |
We performed retrograde-labeling of these cells with 4Di-10ASP in adult mice 7 days after NC, purified the RGCs with fluorescence-activated cell sorting. Gene expression in the cells was determined with a microarray, and the expression of Ho-1 was determined with quantitative PCR (QPCR). The microarray and QPCR analyses showed increased expression of Ho-1 in the post-NC RGCs. Immunohistochemistry also showed that HO-1 positive cells were present in the ganglion cell layerafter NC.
To evaluate the association between ocular blood flow and biomarkers of systemic oxidative stress, as well as the potential of these biomarkers to assess normal-tension glaucoma (NTG). This study included 73 eyes of 73 patients with NTG.Urinary 8-OHdG were both correlated with tissue-area MBR (P = 0.010, respectively).We suggest that systemic oxidative stress is associated with decreased ocular blood flow and may be involved in the pathogenesis of NTG.
|
Report
(3 results)
Research Products
(7 results)
