Photoreceptor-specific role of mitochondria

Research Project

Project/Area Number	26861437
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	The University of Tokyo
Principal Investigator	Ueta Takashi 東京大学, 医学部附属病院, 登録研究員 (90631573)
Research Collaborator	ROGGIA Murilo F. AMANO Shiro
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	網膜変性 / ミトコンドリア異常 / 視細胞 / transcriptional factor A / transcription factor A / ミトコンドリア
Outline of Final Research Achievements	Mouse lacking transcription factor A (TFAM) in photoreceptor cells were created to test the importance of the gene in photoreceptors. Interestingly, The TFAM deficient photoreceptor precursors were able to differentiated into cone and rod photoreceptors, but then followed by cone-rod dystrophy phenotypes.

Report

(4 results)