Second eye involvement in unilateral age-related macular degeneration

• Project/Area Number: 26861441
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Yamanashi
• Principal Investigator: SAKURADA Yoichi 山梨大学, 総合研究部, 助教 (90456476)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 加齢黄斑変性 / 僚眼発症 / 遺伝子多型 / ポリープ状脈絡膜血管症

Outline of Final Research Achievements

We studied 179 patients with initial unilateral PCV . 20 (11%) of 179 patients developed PCV in the initially unaffected fellow eye. The risk allele of ARMS2 A69S was significantly more prevalent in patients with second eye involvement compared to those without PCV in the fellow eye.Survival analysis revealed that the fellow eye of patients with the risk-associated high-risk genotype of ARMS2 A69S was affected significantly earlier than those with other genotypes.Development of PCV in the unaffected fellow eye is associated with ARMS2 A69S genotype in patients with unilateral PCV

Research Products

• [Journal Article] Incidence and risk factors of retreatment after three-monthly aflibercept therapy for exudative age-related macular degeneration (2017)
  • Author(s): Kikushima W, Sakurada Y, Yoneyama S, Sugiyama A, Tanabe N, Kume A, Mabuchi F, Iijima H
  • Journal Title: Scientific reports Volume: ７ Issue: 1 Pages: 44020-44020
  • DOI: 10.1038/srep44020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration (2017)
  • Author(s): Shijo T, Sakurada Y, Yoneyama S, Sugiyama A, Kikushima W, Tanabe N, Iijima H
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 印刷中 Issue: 6 Pages: 1125-1131
  • DOI: 10.1007/s00417-017-3622-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CHOROIDAL THICKNESS AS A PROGNOSTIC FACTOR OF PHOTODYNAMIC THERAPY WITH AFLIBERCEPT OR RANIBIZUMAB FOR POLYPOIDAL CHOROIDAL VASCULOPATHY (2017)
  • Author(s): Sakurada Y, Sugiyama A, Tanabe N, Kikushima W, Kume A, Iijima H
  • Journal Title: RETINA Volume: 印刷中 Issue: 10 Pages: 1866-1872
  • DOI: 10.1097/iae.0000000000001427
  • Peer Reviewed
• [Journal Article] Retreatment of polypoidal choroidal vasculopathy after photodynamic therapy combined with intravitreal ranibizumab (2017)
  • Author(s): Kikushima W, Sakurada Y, Sugiyama A, Tanabe N, Yoneyama S, Iijima H
  • Journal Title: Jpn J Ophthalmol Volume: 61 Issue: 1 Pages: 61-66
  • DOI: 10.1007/s10384-016-0479-4
  • NAID: 210000180174
  • Peer Reviewed
• [Journal Article] Comparison of initial treatment between 3-monthly intravitreal aflibercept monotherapy and combined photodynamic therapy with single intravitreal aflibercept for polypoidal choroidal vasculopathy (2017)
  • Author(s): Kikushima W, Sakurada Y, Sugiyama A, Tanabe N, Kume A, Iijima H
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 255 Issue: 2 Pages: 311-316
  • DOI: 10.1007/s00417-016-3467-y
  • Peer Reviewed
• [Journal Article] Prevalence and Genetic Characteristics of Geographic Atrophy among Elderly Japanese with Age-Related Macular Degeneration (2016)
  • Author(s): Sakurada Y, Yoneyama S, Sugiyama A, Tanabe N, Kikushima W, Mabuchi F, Kume A, Kubota T, Iijima H.
  • Journal Title: PloS ONE Volume: 11(2) Issue: 2 Pages: e0149978-e0149978
  • DOI: 10.1371/journal.pone.0149978
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration (2015)
  • Author(s): Sakurada Y, Nakamura Y, Yoneyama S, Mabuchi F, Gotoh T, Tateno Y, Sugiyama A, Kubota T, Iijima H.
  • Journal Title: Ophthalmic Res Volume: 53(1) Issue: 1 Pages: 2-7
  • DOI: 10.1159/000365487
• [Journal Article] Risk factors for second eye involvement in eyes with unilateral polypoidal choroidal vasculopathy (2015)
  • Author(s): Tateno Y,Sakurada Y,Yoneyeam S,Kikushima W,Mabuchi F,Sugiyama A,Tanabe N,Kubota T,Iijima H
  • Journal Title: Ophthalmic Genetics Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The association of elastin gene variants with two angiographic subtypes of polypoidal choroidal vasculopathy. (2015)
  • Author(s): Yanagisawa S, Sakurada Y, Miki A, Matsumiya W, Imoto I, Honda S.
  • Journal Title: PLOS ONE Volume: 10(3)
  • NAID: 120006872350
  • Peer Reviewed / Open Access
• [Journal Article] New loci and coding variants confer risk for age-related macular degeneration in East Asians. (2015)
  • Author(s): Cheng CY, Yamashiro K, et al.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 6063-6063
  • DOI: 10.1038/ncomms7063
  • NAID: 40020618531
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma (2015)
  • Author(s): Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S.
  • Journal Title: Am J Ophthalmol Volume: 159(3) Pages: 437-44
• [Remarks] 山梨大学眼科学教室
  • URL: http://www.med.yamanashi.ac.jp/clinical/ophthal/
• [Remarks] 山梨大学医学部眼科学教室ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical/ophthal/
• [Remarks] 山梨大学眼科ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical/ophthal/