Quantitative analysis of stereopsis in patients with strabismus using three-dimensional images

• Project/Area Number: 26861451
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University (2015-2017); Kawasaki Medical School (2014)
• Principal Investigator: Miyata Manabu 京都大学, 医学研究科, 助教 (00548505)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 立体視 / 斜視 / 網膜 / Nagahama Study / 3D / 立体感覚 / Bangerter filter / 回旋偏位 / 網膜色素変性 / クリスタリン網膜症 / OCT angiography / 両眼視 / 斜視の原因 / 強度近視 / 網膜変性疾患 / 上下回旋斜視 / slant感覚

Outline of Final Research Achievements

We quantitatively measured degree of stereopsis induced by visual targets with 1―5° binocular crossed disparities presented on a three-dimensional television display in healthy subjects and patients with strabismus. The degree of stereopsis in healthy subjects was similar with geometric theoretical values. Furthermore, the degree of stereopsis was not degraded by the reduced monocular visual acuity induced by the use of a 0.3 Bangerter filter. The present study indicates that the use of 0.3 Bangerter filters is considered safer than occlusion eye patches for the patients with normal binocular vision.
The degree of stereopsis in a patient with intermittent exotropia and a patient with postoperative late onset esotropia was 60―70% compared to geometric theoretical values. The present study indicates that strabismic patients with stereopsis feel less popped-out in watching three-dimensional images compared to healthy subjects.

Research Products

• [Journal Article] MACULAR ATROPHY AND MACULAR MORPHOLOGY IN AFLIBERCEPT-TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. (2018)
  • Author(s): Kuroda Y, Yamashiro K, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyata M, Hata M, Takahashi A, Wakazono T, Yoshimura N, Tsujikawa A
  • Journal Title: Retina Volume: 印刷中 Issue: 9 Pages: 1743-1750
  • DOI: 10.1097/iae.0000000000001765
  • Peer Reviewed
• [Journal Article] Predictive factors for corrective effect of inferior rectus recession for congenital superior oblique palsy. (2018)
  • Author(s): Miyata M, Shibata K, Hamasaki I, Hata M, Muraoka Y, Yoshikawa M, Hasebe S, Ohtsuki H
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 256 Issue: 2 Pages: 403-409
  • DOI: 10.1007/s00417-017-3838-z
  • NAID: 120006416229
  • Peer Reviewed
• [Journal Article] Multimodal Imaging for Differential Diagnosis of Bietti Crystalline Dystrophy (2018)
  • Author(s): Oishi A, Oishi M, Miyata M, Hirashima T, Hasegawa T, Numa S, Tsujikawa A
  • Journal Title: Ophthalmology Retina Volume: 印刷中 Issue: 10 Pages: 1071-1077
  • DOI: 10.1016/j.oret.2018.02.012
  • Peer Reviewed
• [Journal Article] Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography. (2018)
  • Author(s): Miyata M, Oishi A, Hasegawa T, Ishihara K, Oishi M, Ogino K, Sugahara M, Hirashima T, Hata M, Yoshikawa M, Tsujikawa A.
  • Journal Title: Br J Ophthalmol Volume: 印刷中 Issue: 9 Pages: 1208-1212
  • DOI: 10.1136/bjophthalmol-2017-311313
  • Peer Reviewed
• [Journal Article] Age-related change and sex difference over 60s in disc-fovea angle in Japanese population: the Nagahama Study. (2018)
  • Author(s): Miyata M. Yoshikawa M. Ohtsuki H. Muraoka Y. Hata M. Yokota S. Fujimoto M. Miyake M. Tabara Y. Matsuda F. Yoshimura N.
  • Journal Title: Acta Ophthalmol. Volume: in press Issue: 7
  • DOI: 10.1111/aos.13642
  • NAID: 120006630978
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa. (2017)
  • Author(s): Sugahara M, Miyata M, Ishihara K, Gotoh N, Morooka S, Ogino K, Hasegawa T, Hirashima T, Yoshikawa M, Hata M, Muraoka Y, Ooto S, Yamashiro K, Yoshimura N
  • Journal Title: Sci Rep Volume: 13 Issue: 1 Pages: 46396-46396
  • DOI: 10.1038/srep46396
  • NAID: 120006222006
  • Peer Reviewed / Open Access
• [Journal Article] Association of SIX1/SIX6 locus polymorphisms with regional circumpapillary retinal nerve fibre layer thickness: The Nagahama study. (2017)
  • Author(s): Yoshikawa M. Yamashiro K. Nakanishi H. Miyata M. Miyake M. Hosoda Y. Tabara Y. Matsuda F. Yoshimura N. Nagahama Study Group.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 4393-4393
  • DOI: 10.1038/s41598-017-02299-7
  • NAID: 120006368160
  • Peer Reviewed / Open Access
• [Journal Article] Association of Vascular Versus Avascular Subretinal Hyperreflective Material With Aflibercept Response in Age-related Macular Degeneration. (2017)
  • Author(s): Kawashima Y, Hata M, Oishi A, Ooto S, Yamashiro K, Tamura H, Miyata M, Uji A, Ueda-Arakawa N, Tsujikawa A
  • Journal Title: Am J Ophthalmol Volume: 181 Pages: 61-70
  • DOI: 10.1016/j.ajo.2017.06.015
  • Peer Reviewed
• [Journal Article] Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations. (2017)
  • Author(s): Hirashima T, Miyata M, Ishihara K, Hasegawa T, Sugahara M, Ogino K, Yoshikawa M, Hata M, Kuroda Y, Muraoka Y, Ooto S, Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 58 Issue: 10 Pages: 3871-3878
  • DOI: 10.1167/iovs.17-21515
  • NAID: 120006345020
  • Peer Reviewed
• [Journal Article] CHOROIDAL AND RETINAL ATROPHY OF BIETTI CRYSTALLINE DYSTROPHY PATIENTS WITH CYP4V2 MUTATIONS COMPARED TO RETINITIS PIGMENTOSA PATIENTS WITH EYS MUTATIONS. (2017)
  • Author(s): Miyata M, Hata M, Ooto S, Ogino K, Gotoh N, Morooka S, Hasegawa T, Hirashima T, Sugahara M, Kuroda Y, Yamashiro K, Yoshimura N.
  • Journal Title: Retina Volume: 印刷中
  • NAID: 120006313613
  • Peer Reviewed
• [Journal Article] Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study. (2017)
  • Author(s): Hata M, Oishi A, Muraoka Y, Miyamoto K, Kawai K, Yokota S, Fujimoto M, Miyata M, Yoshimura N.
  • Journal Title: J Neuroophthalmol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] RETINAL PIGMENT EPITHELIAL ATROPHY AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS FOR RETINAL ANGIOMATOUS PROLIFERATION. (2017)
  • Author(s): Hata M, Yamashiro K, Oishi A, Ooto S, Tamura H, Miyata M, Ueda-Arakawa N, Kuroda Y, Takahashi A, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Inner Segment Ellipsoid Band Length is a Prognostic factor in Retinitis Pigmentosa Associated with EYS mutations: 5-year Observation of Retinal Structure (2017)
  • Author(s): Miyata M, Ogino K, Gotoh N, Morooka S, Hasegawa T, Hata M, Yoshimura N.
  • Journal Title: Eye Volume: 印刷中
  • NAID: 120006313611
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa (2017)
  • Author(s): Sugahara M, Miyata M, Ishihara K, Gotoh N, Morooka S, Ogino K, Hasegawa T, Hirashima T, Yoshikawa M, Hata M, Muraoka Y, Ooto S, Yamashiro K, Yoshimura N.
  • Journal Title: Sci Rep Volume: 印刷中
  • NAID: 120006222006
  • Peer Reviewed
• [Journal Article] Detection of Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography. (2016)
  • Author(s): Miyata M, Ooto S, Hata M, Yamashiro K, Tamura H, Akagi-Kurashige Y, Nakanishi H, Ueda-Arakawa N, Takahashi A, Kuroda Y, Wakazono T, Yoshikawa M, Yoshimura N.
  • Journal Title: Am J Ophthalmol. Volume: 165 Pages: 108-14
  • DOI: 10.1016/j.ajo.2016.03.009
  • Peer Reviewed
• [Journal Article] Quantitative comparison of disc rim color in optic nerve atrophy of compressive optic neuropathy and glaucomatous optic neuropathy. (2016)
  • Author(s): Nakano E, Hata M, Oishi A, Miyamoto K, Uji A, Fujimoto M, Miyata M, Yoshimura N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 254 Issue: 8 Pages: 1609-16
  • DOI: 10.1007/s00417-016-3366-2
  • Peer Reviewed
• [Journal Article] Quantitative Analysis of the Effects of a Bangerter Filter on Gross Stereopsis in Experimental Models of Reduced Visual Acuity. (2016)
  • Author(s): Miyata M, Nakahara R, Hamasaki I, Hasebe S, Furuse T, Ohtsuki H.
  • Journal Title: Acta Med Okayama Volume: 70 Pages: 339-344
  • NAID: 120006312257
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intraocular Vascular Endothelial Growth Factor Levels in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular DegenerationIntraocular VEGF in nAMD. (2016)
  • Author(s): Hata M, Yamashiro K, Ooto S, Oishi A, Tamura H, Miyata M, Ueda-Arakawa N, Takahashi A, Tsujikawa A, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Issue: 1 Pages: 292-298
  • DOI: 10.1167/iovs.16-20967
  • Peer Reviewed
• [Journal Article] Quantitative analysis of the effects of a Bangerter filter on gross stereopsis in experimental models of reduced visual acuity (2016)
  • Author(s): Manabu Miyata, Ryuichi Nakahara, Ichiro Hamasaki, Satoshi Hasebe, Takashi Furuse, and Hiroshi Ohtsuki
  • Journal Title: Acta Medica Okayama Volume: -
  • NAID: 120006312257
  • Peer Reviewed
• [Presentation] 斜視の診断と治療 (2018)
  • Author(s): 宮田学
  • Organizer: 第31回京都府眼科学校医研修会
  • Invited
• [Presentation] より上質な斜視手術をめざして (2018)
  • Author(s): 宮田学
  • Organizer: 第51回京都眼科フォーラム
  • Invited
• [Presentation] 斜視手術の術前検査について～執刀医の立場から～ (2017)
  • Author(s): 宮田学
  • Organizer: 京滋コメディカルセミナー
  • Invited
• [Presentation] 先天上斜筋麻痺に対する下直筋後転術の矯正効果に影響を与える因子 (2017)
  • Author(s): 宮田 学、大月 洋、村岡勇貴、畑 匡侑、横田 聡、藤本雅大、須田謙史、中西秀雄、辻川明孝
  • Organizer: 京都眼科学会
• [Presentation] Quantitative Analysis of Stereopsis in Experimental Models of Reduced Visual Acuity Induced with Bangerter Filter Using a Three-Dimensional Television (2014)
  • Author(s): Miyata M, Nakahara R, Hamasaki I, Ohtsuki H, Shiraga F.
  • Organizer: WOC 2014
  • Place of Presentation: Tokyo
  • Year and Date: 2014-04-02 – 2014-04-06
• [Book] 専門医のための眼科診療クオリファイ22 弱視・斜視診療のスタンダード 「外眼筋の作用」 (2014)
  • Author(s): 宮田 学（分担執筆）
  • Publisher: 中山書店