Investigation and new therapeutic strategy for the hyperpermeability of the diabetic retinal vessels

Research Project

Project/Area Number	26861454
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Kyushu University
Principal Investigator	Arita Ryoichi 九州大学, 大学病院, その他 (30621289)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	血管透過性亢進 / 糖尿病網膜症 / Rho kinase
Outline of Final Research Achievements	Diabetic macular edema is well-known ocular complication and the leading cause of poor visual impairment in diabetes. Diabetic macular edema beaks down the blood-retinal barrier, leading to fluid leakage from abnormal retinal capillaries. This study investigates that ROCK plays a significant role for barrier functions of vascular　permeability. ROCK inhibitor recovered diabetes-induced barrier disruption and vascular hyperpermeability. These data indicates ROCK inhibitor has the ameliorating effect on diabetes-induced macular edema via blockade of vascular permeability.

Report

(3 results)