Investigation and new therapeutic strategy for the hyperpermeability of the diabetic retinal vessels
| Project/Area Number |
26861454
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
Arita Ryoichi 九州大学, 大学病院, その他 (30621289)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 血管透過性亢進 / 糖尿病網膜症 / Rho kinase |
|---|
| Outline of Final Research Achievements |
Diabetic macular edema is well-known ocular complication and the leading cause of poor visual impairment in diabetes. Diabetic macular edema beaks down the blood-retinal barrier, leading to fluid leakage from abnormal retinal capillaries.
This study investigates that ROCK plays a significant role for barrier functions of vascular permeability. ROCK inhibitor recovered diabetes-induced barrier disruption and vascular hyperpermeability. These data indicates ROCK inhibitor has the ameliorating effect on diabetes-induced macular edema via blockade of vascular permeability.
|
Report
(3 results)
Research Products
(3 results)
-
[Journal Article] Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia.2016
Author(s)
Yamaguchi M, Nakao S, Arita R, Kaizu Y, Arima M, Zhou Y, Kita T, Yoshida S, Kimura K, Isobe T, Kaneko Y, Sonoda KH, Ishibashi T.
-
Journal Title
Invest Ophthalmol Vis Sci
Volume: 57
Issue: 4
Pages: 2264-2276
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
