The importance of EMT in RPE cells
| Project/Area Number |
26861457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Takahashi Eri 熊本大学, 大学院生命科学研究部(医), 助教 (60622602)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 網膜色素上皮 / 上皮間葉転換 / TNF-α / ERMタンパク質ファミリー / ｐ３８MAPK / TAK1 / ＴＮＦ－α / ＥＲＭタンパク質ファミリー / ｐ３８ＭＡＰＫ / ＴＡＫ１ / 網膜色素上皮細胞 / Merlin |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) is associated with ocular fibrosis, especially proliferative vitreoretinopathy and subretinal fibrosis in age-related macular disease. We found that Merlin, one of ERM protein family, is essential for maintenance of epithelial phenotype in retinal pigment epithelial (RPE) cells. Tumor necrosis factor (TNF)-alpha is an inducer of EMT in RPE cells and TNF-α decreased the expression of Merlin, leading to phosphorlation of ERM proteins, p38MAPK via TAK1. TAK1-p38MAPK signaling pathway plays an important role in TNF-α-induced EMT in RPE cells.
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Report
(4 results)
Research Products
(14 results)
