The role of Dock molecules in glaucoma and optic neuritis
Project/Area Number |
26861479
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
KIMURA Atsuko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 (60569143)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | バルプロ酸 / 緑内障 / 神経保護 / 神経変性疾患 |
Outline of Final Research Achievements |
We examine neuroprotective effects of Valproic acid (VPA) in glutamate-induced excitotoxicity model, which mimics some of the pathological features of glaucoma. In vivo retinal imaging using optical coherence tomography revealed that glutamate -induced retinal degeneration was suppressed in the VPA-treated retina, and histological analyses confirmed that VPA reduced retinal ganglion cell death. In vivo electrophysiological analyses demonstrated that visual impairment was prevented in the VPA-treated etina, clearly establishing both histological and functional effects of VPA. Our findings raise intriguing possibilities that VPA may be useful for treatment of glaucoma.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] TrkB signaling in retinal glia stimulates neuroprotection after optic nerve injury.2015
Author(s)
Harada, C., Azuchi, Y., Noro, T., Guo, X., Kimura, A., Namekata, K., Harada, T.
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Journal Title
American Journal of Pathology
Volume: 185
Issue: 12
Pages: 3238-3247
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.2015
Author(s)
Noro, T., Namekata, K., Kimura, A., Guo, X., Azuchi, Y., Harada, C., Nakano, T., Tsuneoka, H. and Harada, T.
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Journal Title
Cell Death and Disease
Volume: 6
Issue: 4
Pages: e1720-e1720
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Spermidine ameliorates neurodegeneration in a mouse model of normal tension glaucoma.2015
Author(s)
Noro, T., Namekata, K., Azuchi, Y., Kimura, A., Guo, X., Harada, C., Nakano, T., Tsuneoka, H., Harada, T.
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 56
Issue: 8
Pages: 5012-5019
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Valproic acid prevents NMDA-induced retinal ganglion cell death via stimulation of neuronal TrkB receptor signaling2015
Author(s)
Kimura, A., Namekata, K., Guo, X., Noro, T., Harada, C. and Harada, T.
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Journal Title
American Journal of Pathology
Volume: 185
Issue: 3
Pages: 756-764
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma2015
Author(s)
Kimura, A., Guo, X., Noro, T., Harada, C., Tanaka, K., Namekata, K. and Harada, T
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Journal Title
Neuroscience Letters
Volume: 588
Pages: 108-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis2015
Author(s)
Guo, X., Namekata, K., Kimura, A., Noro, T., Azuchi, Y., Semba, K., Harada, C., Yoshida, H., Mitamura, Y. and Harada, T.
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Journal Title
Neuroscience Letters
Volume: 592
Pages: 27-31
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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