Functional analysis of Shf in neuroblastoma

• Project/Area Number: 26861484
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Nagoya City University
• Principal Investigator: TAKAGI Daisuke 名古屋市立大学, 大学院医学研究科, 助教 (60611580)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 神経芽腫

Outline of Final Research Achievements

We previously identified Src homology 2 domain containing F as one of the adaptor protein expressed at high levels in favorable neuroblastoma. We also found that Shf interacted with anaplastic lymphoma kinase (ALK), an oncogenic receptor tyrosine kinase in neuroblastoma. Shf was already known to interact with PDGF receptor and TrkA. In this work, we attempted to elucidate the additional function of Shf. However, we could not produce sufficient result in the term.