The development of fetal therapy in model of congenital diaphragmatic hernia
| Project/Area Number |
26861485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Sakai Kohei 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30515292)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 先天性横隔膜ヘルニア / nitrofen / 胎児治療 / bombesin / ニトロフェン / ラット / ボンベシン / 横隔膜ヘルニア |
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| Outline of Final Research Achievements |
Congenital diaphragmatic hernia (CDH) is a disease that has a still high mortality rate among neonatal surgical diseases. In our facility, intensive care based on gentle vetilation gained marked improvement in survival rate. However, patients who have severe pulmonary hypoplasia can not be rescued. In order to develop fetal therapy for severe cases, administration of neuropeptide bombesin to congenital diaphragmatic hernia model rat increased lung body weight ratio, decreased cell growth factor, type 2 alveolar epithelial cells Results leading to lung maturation such as reduction could be obtained. As for the effect of combined use with other drugs, it is impossible to obtain sufficient results and it is a future subject.
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Report
(4 results)
Research Products
(3 results)
