Establishment of pathology and surgical treatment for idiopathic lymphedema, chylothorax, and chyloabdomen

• Project/Area Number: 26861493
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Hisako Hara 東京大学, 医学部附属病院, 助教 (50624243)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 特発性リンパ浮腫 / 原発性リンパ浮腫 / リンパ管静脈吻合術 / LVA / 乳糜胸水 / 乳糜腹水 / インドシアニングリーン / ICG / 乳糜胸腹水 / 病理 / リンパ節移植

Outline of Final Research Achievements

We have elucidated the efficacy of lymphatico venous anastomosis (LVA) for idiopathic lymphedema. LVA was more effective when the age of onset of idiopathic lymphedema was old. The efficacy of LVA also had a relathionship with the findings of indocyanine green (ICG) lymphography. We performed ICG lymphography to idiopathic chylothorax and chyloabdomen. The prognosis got worse as the findings of ICG lymphography got severe.

Research Products

• [Journal Article] Indication of Lymphaticovenous Anastomosis for Lower Limb Primary Lymphedema. (2015)
  • Author(s): Hara H, Mihara M, Ohtsu H, Narushima M, Iida T, Koshima I.
  • Journal Title: Plastic and Reconstructive Surgery Volume: Oct;136(4): Issue: 4 Pages: 883-93
  • DOI: 10.1097/prs.0000000000001631
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Indocyanine green lymphography and lymphaticovenous anastomosis for generalized lymphatic dysplasia with pleural effusion and ascites in neonates. (2015)
  • Author(s): Mihara M, Hara H, Shibasaki J, Seki Y, Hayashi A, Iida T, Adachi S, Uchida Y, Kaneko H, Haragi M, Murakami A.
  • Journal Title: Annals of Vascular Surgery Volume: Aug;29(6): Issue: 6 Pages: 1111-22
  • DOI: 10.1016/j.avsg.2015.02.013
  • Peer Reviewed
• [Journal Article] Evaluation of lymphatic dysplasia in patients with congenital pleural effusion and ascites using indocyanine green lymphography. (2014)
  • Author(s): Shibasaki J, Hara H, Mihara M, et al.
  • Journal Title: J Pediatr. Volume: 164(5) Issue: 5 Pages: 1116-1120
  • DOI: 10.1016/j.jpeds.2013.12.052
  • Peer Reviewed
• [Presentation] 特発性リンパ疾患に対するわれわれのアプローチ (2016)
  • Author(s): 原 尚子
  • Organizer: 日本形成外科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-04-13
• [Presentation] 原発性リンパ浮腫に対するリンパ管静脈吻合術(LVA)の効果 (2015)
  • Author(s): 原 尚子
  • Organizer: 国際リンパ浮腫フレームワークジャパン研究協議会第5回学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-09-21
• [Presentation] Indication of LVA for primary lower limb lymphedema (2015)
  • Author(s): Hisako Hara
  • Organizer: World Congress of Lymphology
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] 原発性リンパ浮腫に対するわれわれのアプローチ (2015)
  • Author(s): 原 尚子
  • Organizer: 日本形成外科学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-08
• [Presentation] リンパ浮腫について (2015)
  • Author(s): 原尚子
  • Organizer: 第1回福岡大学リンパ浮腫研究会
  • Place of Presentation: 福岡
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] Lymphatico-venous anastomosis for primary and secondary lymphedema (2014)
  • Author(s): Hisako Hara
  • Organizer: International lymphoedema symposium
  • Place of Presentation: パリ
  • Year and Date: 2014-12-10
  • Invited
• [Presentation] 原発性リンパ浮腫に対するわれわれのアプローチ (2014)
  • Author(s): 原尚子
  • Organizer: 日本マイクロサージャリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] リンパ浮腫およびそれに伴う皮膚病変の病理学的検討 (2014)
  • Author(s): 原尚子
  • Organizer: 日本マイクロサージャリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] リンパ浮腫に伴う皮膚病変の病理学的検討 (2014)
  • Author(s): 原尚子
  • Organizer: 形成外科学会基礎学術集会
  • Place of Presentation: 長野
  • Year and Date: 2014-10-09 – 2014-10-10
• [Presentation] Our Diagnostic and Therapeutic Approaches to Primary Lymphoedema. (2014)
  • Author(s): Hisako Hara
  • Organizer: 40th ESL Congress
  • Place of Presentation: Genoa
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Comparison of Indocyanine Green Lymphographic findings with the Conditions of collecting (2014)
  • Author(s): Hisako Hara
  • Organizer: 40th ESL Congress
  • Place of Presentation: Genoa
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 特発性リンパ管形成不全に対するわれわれのアプローチ (2014)
  • Author(s): 原尚子
  • Organizer: 日本静脈学会総会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-04-17 – 2014-04-18
• [Funded Workshop] 25th World Congress of Lymphology (2015)
  • Place of Presentation: San Fransisco
  • Year and Date: 2015-09-07