Development and application of bioimaging technology to contribute to the spatiotemporal and functional analysis in inflammatory miRNA
| Project/Area Number |
26861503
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANAKA Katsuya 長崎大学, 病院(医学系), 医員 (70722750)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | miRNA / 炎症 / イメージング / 皮膚創傷治癒 / 炎症細胞 |
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| Outline of Final Research Achievements |
This study has been performed to elucidate the organizational and molecular correlation influencing on tissue repair mechanism including scar formation by spatiotemporal dynamics of inflammatory cells at skin wound. And we achieved to identify the skin wound inflammation-related microRNA (miRNA) which was noted having various functions. Furthermore, we produced the miRNA knockout mice and revealed that the one of inflammation-related miRNA affected the phagocytosis and infection control function of neutrophils having a central role in innate immunity by using bioimaging technique. The imaging techniques used in this study that employed a confocal fluorescent microscope can be a technique that is widely used in the world.
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Report
(3 results)
Research Products
(7 results)
