| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Cranioplasty for defects of the skull is generally performed with nonabsorbable materials or autologous bone. However, these materials are occasionally associated with complication such as infection and donor-site morbidities. Platelet-rich plasma(PRP) promotes wound healing and bone regeneration and its clinical use is rapidly spread. Therefore, we investigated whether a combination of PRP and β-TCP as biodegradable osteoinductive materials could be cut down for bone healing period. Our result also suggested that the slow and continuous release of growth factor from PRP can promote bone regeneration more powerfully, so this material can be safe and effective bone filler.
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