| Project/Area Number |
26861513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
SUDA Shunichi 順天堂大学, 医学部, 非常勤助手 (70645861)
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| Research Collaborator |
TANAKA Rica 順天堂大学, 医学部, 准教授 (70509827)
TOBITA Morikuni 順天堂大学, 医学部, 准教授 (10599038)
MIZUNO Hiroshi 順天堂大学, 医学部, 教授 (80343606)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 形成外科 / 幹細胞 / 脂肪組織 / 血管内皮細胞 / 再生医療 / 脂肪幹細胞 / 血管内皮前駆細胞 |
|---|
| Outline of Final Research Achievements |
As diabetic patients increase, the patients suffering from non-healing diabetic ulcer also increases and many of them go under lower limb amputations. There is no effective treatment for these patients after treatment modalities are exhausted. One of the etiologies is dysfunction of endothelial progenitor cells (EPC) which is the vascular stem cells in diabetic patients. Here, we focused the functions of adipose tissue-derived stem cells (ASC) in diabetes. We found that ASC were difficult to differentiate to vascular endothelial cells. On the other hands, ASC secreted various angiogenic factors to enhance angiogenesis. However, these founding were decreased in diabetes. ASC enhanced the wound closure and increased the viability of transplanted adipose tissue when mixing with EPC in mice. From these results, we conclude that ASC show strong indirect effects of angiogenesis through the secretion of angiogenic factors and the function is enhanced with co-transplantation with EPCs.
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