| Project/Area Number |
26861519
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Gifu University |
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Principal Investigator |
SUZUKI KODAI 岐阜大学, 医学部附属病院, 医員 (80724583)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 敗血症 / B細胞 / 疲弊 / 加齢 / 免疫グロブリン |
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| Outline of Final Research Achievements |
While B cells are known to play pivotal roles in sepsis, changes in B cell-mediated humoral immunity have not been evaluated. We aimed to investigate changes in humoral immunity caused by defective B cell function during sepsis. Blood was collected to measure B cell subtypes, serum IgM concentration, and CpG-B oligodeoxynucleotide-induced IgM production ex vivo. The fraction of CD21-/low exhausted B cells in septic patients was higher than that observed in healthy donors. Significantly, serum IgM in elderly septic patients was negatively correlated with APACHE II score. Consistently, in B cells stimulated ex vivo, both aging and sepsis induced significant reductions in supernatant IgM. Reduced immunocompetent B cells may be related to increased severity and secondary infection after sepsis, especially in the elderly. Finally, impaired humoral immunity with increased CD21-/low exhausted B cells and insufficient IgM production may be a critical immunological change in sepsis.
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