Elucidation of the mechanism of immune response to trauma - from the view of the balance between innate and adoptive immune system -

• Project/Area Number: 26861522
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Osaka University
• Principal Investigator: Osuka Akinori 大阪大学, 医学(系)研究科(研究院), 特任研究員 (60552081)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 外傷 / 免疫 / 熱傷 / インフラマソーム / 制御性T細胞 / DAMPs

Outline of Final Research Achievements

Inflammasome, one of the pattern recognition receptors which activate inflammatory cascade, and regulatory T cells which activate anti-inflammatory cascade, were activated following severe burn injury. The cytokine profiling was also supported their activations. Damage associated molecular pattern molecules might be associated with the activation of the inflammasome and regulatory T cells. So far, we could not conclude that the activation of inflammasome or regulatory T cells cause death or organ failure.