Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
Inflammasome, one of the pattern recognition receptors which activate inflammatory cascade, and regulatory T cells which activate anti-inflammatory cascade, were activated following severe burn injury. The cytokine profiling was also supported their activations. Damage associated molecular pattern molecules might be associated with the activation of the inflammasome and regulatory T cells. So far, we could not conclude that the activation of inflammasome or regulatory T cells cause death or organ failure.
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