Efficacy and role of myocardial ischemic preconditioning via activate signaling pathway by SOCS3-CKO in myocardial ischemia repercussion injury
Project/Area Number |
26861537
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
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Research Institution | Kurume University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | SOCS3 / JAK-STAT signaling / ischemia reperfusion / ischemic preconditioning / 心筋プレコンディショニング / JAK-STAT経路 / preconditioning |
Outline of Final Research Achievements |
I investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the JAK-STAT signaling pathway, in the pathophysiology of myocardial ischemic preconditioning (IPC) and myocardial ischemia-reperfusion injury (IRI). Activation of STAT3 was rapidly peaked and was inactivated after IPC. The infarct size 24 hour after IRI was reduced in SOCS3-CKO. These results suggested that progression of myocardial IRI was prevented in SOCS3-CKO hearts. Cardiac-specific SOCS3 deletion enhanced cardioprotective signaling pathway by ischemic preconditioning.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Cardiac-specific SOCS3 deletion prevents in vivo myocardial ischemia reperfusion injury through sustained activation of cardioprotective signaling molecules2015
Author(s)
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T, Mawatari K, Shimozono K, Pradeavand S, Hoshijima M, Aoki H, Fukumoto Y, Imaizumi T
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning2015
Author(s)
Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T
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Journal Title
Circulation Journal
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.2014
Author(s)
Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.
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Journal Title
J Am Coll Cardiol
Volume: 63
Issue: 24
Pages: 2722-2733
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Prevention of Myocardial Ischemia-Reperfusion Injury in Cardiac-Specific SOCS3 Knockout Mice by enhanced activation of vardioprotective signaling pathways2014
Author(s)
T nagata, H Yasukawa, T Oba, S Pradervand, K mawatari, S Kyogoku, H Ohshima, T Minami, K Sasaki, T Yajima, M Hoshijima, Kirk U Knowlton, T Imaizumi, Y Fukumoto
Organizer
第18回日本心不全学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-10 – 2014-10-12
Related Report
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