Efficacy and role of myocardial ischemic preconditioning via activate signaling pathway by SOCS3-CKO in myocardial ischemia repercussion injury

• Project/Area Number: 26861537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kurume University
• Principal Investigator: NAGATA Takanobu 久留米大学, 医学部, 助教 (50535078)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: SOCS3 / JAK-STAT signaling / ischemia reperfusion / ischemic preconditioning / 心筋プレコンディショニング / JAK-STAT経路 / preconditioning

Outline of Final Research Achievements

I investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the JAK-STAT signaling pathway, in the pathophysiology of myocardial ischemic preconditioning (IPC) and myocardial ischemia-reperfusion injury (IRI). Activation of STAT3 was rapidly peaked and was inactivated after IPC. The infarct size 24 hour after IRI was reduced in SOCS3-CKO. These results suggested that progression of myocardial IRI was prevented in SOCS3-CKO hearts. Cardiac-specific SOCS3 deletion enhanced cardioprotective signaling pathway by ischemic preconditioning.

Research Products

• [Journal Article] Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. (2015)
  • Author(s): Nagata Takanobu
  • Journal Title: PLOS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] Cardiac-specific SOCS3 deletion prevents in vivo myocardial ischemia reperfusion injury through sustained activation of cardioprotective signaling molecules (2015)
  • Author(s): Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T, Mawatari K, Shimozono K, Pradeavand S, Hoshijima M, Aoki H, Fukumoto Y, Imaizumi T
  • Journal Title: PLOS ONE Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning (2015)
  • Author(s): Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T
  • Journal Title: Circulation Journal Volume: 印刷中
  • NAID: 130005083944
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. (2014)
  • Author(s): Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.
  • Journal Title: J Am Coll Cardiol Volume: 63 Issue: 24 Pages: 2722-2733
  • DOI: 10.1016/j.jacc.2014.03.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 既存のがん緩和ケアチームと協働する循環器緩和ケアシステムの構築 (2015)
  • Author(s): 柴田龍宏、永田隆信
  • Organizer: 循環器心身医学会総会
  • Place of Presentation: 大分市労済ソレイユ
  • Year and Date: 2015-11-14
• [Presentation] Cardiac-Specific SOCS3 deficiency leads to left ventricular dysfunction with advanced age through impaired autophagy (2015)
  • Author(s): 野原正一郎、永田隆信
  • Organizer: American heart association scientific sessions
  • Place of Presentation: オーランド
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules (2015)
  • Author(s): 永田隆信
  • Organizer: 日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪
  • Year and Date: 2015-10-22
• [Presentation] ERK1/2 Suppressor Sprouty4 Does Not Play an Important Role in the Development of Left Ventricular Remodeling After Acute Myocardial Infarction (2014)
  • Author(s): Mawatari K、Yasukawa H、Oba T、Futamata N、Nagata N、Kyougoku S、Ohshima H、Imaizumi T
  • Organizer: 第31回国際心臓研究学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] Prevention of Myocardial Ischemia-Reperfusion Injury in Cardiac-Specific SOCS3 Knockout Mice by enhanced activation of vardioprotective signaling pathways (2014)
  • Author(s): T nagata, H Yasukawa, T Oba, S Pradervand, K mawatari, S Kyogoku, H Ohshima, T Minami, K Sasaki, T Yajima, M Hoshijima, Kirk U Knowlton, T Imaizumi, Y Fukumoto
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Mechanism of Cardioprotection against Myocardial Infarction by Renal Nerve-mediated Inter- organ Communication. (2014)
  • Author(s): Yasukawa H, Oba T, Nagata T, Fukumoto Y.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: 京都
  • Year and Date: 2014-04-14 – 2014-04-17