| Project/Area Number |
26861539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMADA TAMAKI 北海道大学, 大学病院, 医員 (80580943)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨代謝 / 骨細胞 / FGF23 / 癌細胞 / 骨転移 |
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| Outline of Final Research Achievements |
I focused attention on behavior of osteocytes in bone metastasis foci of cancer cells.Especially, I analyzed on network between osteocytes and cancer cells. I focused attention on FGF23, which is produced by osteocytes and involved in bone metabolism. FGF23 did not express in osteocytes, to which cancer cells metastasized. By contrast, FGF23 expressed abundantly in bone metastasis foci. From these results, I inferred the existence of network between osteocytes and cancer cells. These results showed that FGF23 expression had a lot of involvement in bone metastasis of cancer cells. I research if cancer cells express FGF23 by metastasizing to bone and have directivity to bone.
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