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Investigation of network between cancer cells and osteocyte under circumstance of bone metastasis

Research Project

Project/Area Number 26861539
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionHokkaido University

Principal Investigator

YAMADA TAMAKI  北海道大学, 大学病院, 医員 (80580943)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨代謝 / 骨細胞 / FGF23 / 癌細胞 / 骨転移
Outline of Final Research Achievements

I focused attention on behavior of osteocytes in bone metastasis foci of cancer cells.Especially, I analyzed on network between osteocytes and cancer cells. I focused attention on FGF23, which is produced by osteocytes and involved in bone metabolism. FGF23 did not express in osteocytes, to which cancer cells metastasized. By contrast, FGF23 expressed abundantly in bone metastasis foci. From these results, I inferred the existence of network between osteocytes and cancer cells. These results showed that FGF23 expression had a lot of involvement in bone metastasis of cancer cells. I research if cancer cells express FGF23 by metastasizing to bone and have directivity to bone.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers2016

    • Author(s)
      T.Yamada, M. Tsuda, T. Wagatsuma, Y. Fujioka, M. Fujioka, A. O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, Y. Totsuka, H. Haga, S. Tanaka, M. Shindoh, and Y. Ohba
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 23545-23545

    • DOI

      10.1038/srep23545

    • NAID

      120005753715

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 下顎骨骨髄から発生したと考えられた巨大な悪性リンパ腫の1例2016

    • Author(s)
      山田 珠希、栗林 和代、大廣 洋一、篠原 早紀、松田 光平、鈴木 豊典、北村 哲也、進藤 正信、鄭 漢忠
    • Journal Title

      北海道歯学雑誌

      Volume: 36 Pages: 134-141

    • NAID

      120005725177

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] エナメル上皮腫における歯牙に対する治療法の検討2015

    • Author(s)
      山田 珠希
    • Organizer
      第60回日本口腔外科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科におけるエナメル上皮腫に対する反復処置法の臨床的検討2014

    • Author(s)
      山田 珠希
    • Organizer
      第59回 日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉県、千葉市)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Dredging Method for the Treatment of KCOT2014

    • Author(s)
      Tamaki Yamada
    • Organizer
      AAOMS 96th Annual Meeting, Scientific Sessions and Exhibition in Conjunction with the Japanese Society and Korean Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] RANKL expression in OSCC promotes tumorigenesis and epithelial mesenchymal transition2014

    • Author(s)
      Tamaki Yamada
    • Organizer
      11st ASIAN CONGRESS ON ORAL AND MAXILLOFACIAL SURGERY
    • Place of Presentation
      Xian, China
    • Year and Date
      2014-08-22 – 2014-08-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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