• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Overcome the drug resistance by targeting tumor endothelial markers

Research Project

Project/Area Number 26861540
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionHokkaido University

Principal Investigator

Alam Mohammad Towfik  北海道大学, 歯学研究科, 学術研究員 (60641694)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords腫瘍血管内皮細胞 / がん幹細胞 / 薬剤抵抗性 / 腫瘍血管内皮細胞、 / 血管新生阻害療法
Outline of Final Research Achievements

In this study, to identify tumor endothelial marker (TEC marker) that is involved in drug resistance, drug sensitivity to anti-cancer drug was analyzed using siRNA or inhibitor of TEC markers. The inhibitor of p-glycoprotein encoded by MDR-1 gene, enhanced sensitivity to paclitaxel, in vitro and in vivo. These results suggested that inhibition of TEC markers are possible strategy to overcome drug resistance.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells.2016

    • Author(s)
      *Hida K., Maishi N., Torii C., Yanagiya M., Annan Akuba-Muhyia Dorcas., Morimoto M., Alam Mohammad Towfik
    • Journal Title

      Hokkaido J. Dent. Sci.

      Volume: 37 Pages: 40-48

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.2016

    • Author(s)
      N. Maishi, Y. Ohba, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 28039-28039

    • DOI

      10.1038/srep28039

    • NAID

      120005819304

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property2015

    • Author(s)
      Yamada K., Maishi N., Akiyama K., Alam Mohammad Towfik, Ohga N., Kawamoto T., Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A. and Hida K.
    • Journal Title

      Int J Cancer

      Volume: 137(12) Issue: 12 Pages: 2825-2836

    • DOI

      10.1002/ijc.29655

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel2015

    • Author(s)
      1.Akiyama K., Maishi N., Ohga N., Hida Y., Ohba Y., Alam Mohammad Towfik, Kawamoto T., Ohmura H., Yamada K., Torii C., Shindoh M. and *Hida K.
    • Journal Title

      Am J Pathol

      Volume: 185(2) Issue: 2 Pages: 572-580

    • DOI

      10.1016/j.ajpath.2014.10.017

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suprabasin as a novel tumor endothelial cell marker2014

    • Author(s)
      3.Alam Mohammad Towfik,Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and *Hida K
    • Journal Title

      Cancer Sci

      Volume: 105(12) Issue: 12 Pages: 1533-1540

    • DOI

      10.1111/cas.12549

    • NAID

      120005539218

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016

    • Author(s)
      Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T
    • Organizer
      : The 19th International Vascular Biology Meeting 国際学会
    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor endothelial cells in high metastatic tumors promote metastasis via biglycan,2016

    • Author(s)
      Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Shindoh M., Hida Y. Hida K.
    • Organizer
      The 19th International Vascular Biology Meeting
    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor endothelial cells promote metastasis via biglycan secretion2016

    • Author(s)
      Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Mohammad Towfik Alam, Shindoh M., Hida Y., Hida K
    • Organizer
      Tenth AACR-JCA Joint Conference “Breakthroughs in Cancer Research: From Biology to Therapeutics”
    • Place of Presentation
      Maui (USA)
    • Year and Date
      2016-02-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ROS によるbiglycan 発現誘導を介した腫瘍血管内皮細胞の血管新生能亢進2015

    • Author(s)
      北條敬之,間石奈湖,Mohammad T Alam,秋山廣輔,大賀則孝,進藤正信,樋田泰浩,藤澤俊明,樋田京子
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 腫瘍血管内皮細胞はbiglycan の分泌を介してがんの転移を促進する2015

    • Author(s)
      間石奈湖,大場雄介,秋山廣輔,大賀則孝,浜田淳一,北本(永尾)宗子,Mohammad Alam T.,進藤正信,樋田泰浩,樋田京子
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Tumor endothelial cells promote metastasis via biglycan secretion2015

    • Author(s)
      Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Mohammad Towfik Alam, Shindoh M., Hida Y., Hida K
    • Organizer
      The European Cancer Congress 2015
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 腫瘍血管内皮細胞はbiglycanの分泌を介してがんの転移を促進する2015

    • Author(s)
      間石奈湖,大場雄介,秋山廣輔,大賀則孝,浜田淳一,北本宗子,Alam Mohammad Towfik,進藤正信,樋田泰浩,樋田京子
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館(北海道・札幌市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Suprabasin as a novel tumor endothelial cell marker2015

    • Author(s)
      Alam Mohammad Towfik,Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Shinohara N., Taketomi A.
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館(北海道・札幌市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] P-gp inhibitor enhances antiangiogenic activity in metronomic chemotherapy2014

    • Author(s)
      Akiyama K., Ohga N., Hida Y., Maishi N., Alam Mohammad Towfik, Kawamoto T., Omura H., Yamada Y., Torii C., Shindoh M., Ohba Y., Hida K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都府・京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] SBSN is a novel Tumor Endothelial Cell marker2014

    • Author(s)
      Alam Mohammad Towfik, Nagao H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y., Hida K
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都府・京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] CXCL12/CXCR7 axis is important for tumor endothelial cell angiogenic property2014

    • Author(s)
      Yamada K., Maishi N. Ohga N., Akiyama K., Kawamoto T., Alam Mohammad Towfik, Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A., Hida K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都府・京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Remarks] 北海道大学 遺伝子病制御研究所 フロンティア研究ユニット 血管生物学研究室ホームページ

    • URL

      http://www.igm.hokudai.ac.jp/vascular-biology/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi