Study about mechanism of swallowing disorder in muscle atrophy disease

• Project/Area Number: 26861541
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: SATO TADASU 東北大学, 歯学研究科(研究院), 助教 (40637964)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 神経筋疾患 / 嚥下障害

Outline of Final Research Achievements

The cause of muscle atrophy diseases includes atrophy and degeneration of nerves and/or muscles. The swallowing disorder is known to be a severe symptom of these diseases.
In this study, we examined the changes of muscle and nerves in the pharynx and oral structures in models of muscle atrophy diseases. We also examined the glial reaction in the spinal cord of the models.