| Project/Area Number |
26861544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokyo (2015)
Tokyo Medical and Dental University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 口腔細菌学 / 歯周病原細菌 / ゲノム解析 / CRISPR |
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| Outline of Final Research Achievements |
Among three periodontal pathogens Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, we demonstrated cooperative interactions such as complementation of metabolic pathways as well as competitive interactions in which clustered regularly interspaced short palindromic repeats (CRISPRs), bacterial genomic regions responsible for acquired immunity, were involved. Our findings would be a clue for elucidation of survival strategies of the three pathogens.
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