| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Osteocalcin, in its uncarboxylated form (GluOC), regulates energy metabolism by stimulating insulin secretion, pancreatic β-cell proliferation, and adiponectin expression in the adipocytes. In this study, we showed that there is a sex difference in the effect of GluOC on glucose homeostasis in mouse models. Long-term oral administration of GluOC improved glucose tolerance and decreased adipocyte size in female mice. However, the same treatment caused glucose intolerance, insulin resistance, and adipocyte hypertrophy in male mice. In addition, such administrations of GluOC increased circulating testosterone (T) and decreased serum adiponectin level. These phenotypes disappeared when mice were orchidectomized, and restored again by T supplementation. Moreover, female mice supplemented with T exhibited similar responses to GluOC as male mice. These results suggest that deleterious effect of GluOC is mediated in part by increased circulating T level.
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