Study on abnormality of tumor endothelial cells and hypoxic environment of tumor.
| Project/Area Number |
26861567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kondoh Miyako 北海道大学, 歯学研究科, 助教 (10631864)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 活性酸素種 / 血管内皮細胞 / 低酸素環境 |
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| Outline of Final Research Achievements |
We recently reported that NECs may also acquire chromosomal abnormalities by ROS accumulation due to hypoxia. I examined the behavior of the NECs in the hypoxia state.It was suggested that hypoxia brought chromosome abnormality to a NECs.We have demonstrated that hypoxia causes cytogenetic abnormalities in ECs through ROS accumulation.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS12017
Author(s)
Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.
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Journal Title
Journal of Oral Biosciences
Volume: 59
Pages: 50-54
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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