Study on abnormality of tumor endothelial cells and hypoxic environment of tumor.

• Project/Area Number: 26861567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Hokkaido University
• Principal Investigator: Kondoh Miyako 北海道大学, 歯学研究科, 助教 (10631864)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 活性酸素種 / 血管内皮細胞 / 低酸素環境

Outline of Final Research Achievements

We recently reported that　 NECs may also acquire chromosomal abnormalities by ROS accumulation due to hypoxia. I examined the behavior of the NECs in the hypoxia state.It was suggested that hypoxia brought chromosome abnormality to a NECs.We have demonstrated that hypoxia causes cytogenetic abnormalities in ECs through ROS accumulation.

Research Products

• [Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS1. (2017)
  • Author(s): Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.
  • Journal Title: J Oral Biosci Volume: 59 Issue: 1 Pages: 50-54
  • DOI: 10.1016/j.job.2016.10.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 心因性と特発性の味覚障害患者に対するロフラゼプ酸エチルの効果. (2015)
  • Author(s): 坂田健一郎、山崎 裕、大賀則孝、浅香卓也、近藤美弥子、中澤誠太朗、村井知佳、北川善政
  • Journal Title: 日本歯科心身医学会雑誌 Volume: 29(2) Pages: 60-64
  • Peer Reviewed
• [Journal Article] ロフラゼプ酸エチルが奏効した高齢者味覚障害の2例 (2015)
  • Author(s): 近藤美弥子, 中澤誠多朗, 岡田和隆, 阿部貴惠, 山崎裕
  • Journal Title: 日本歯科心身医学会雑誌 Volume: 29 Pages: 24-27
  • Peer Reviewed
• [Presentation] 行動療法により良好な経過をたどった高齢者味覚障害の1例 (2015)
  • Author(s): 近藤美弥子
  • Organizer: 日本歯科心身医学会
  • Place of Presentation: 東京 東京医科歯科大学M&Dタワー
  • Year and Date: 2015-07-18
• [Presentation] 高齢者における口腔インプラントの予後調査 ―口腔内の有害事象に関して― (2015)
  • Author(s): 近藤美弥子
  • Organizer: 日本老年歯科医学会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2015-06-12
• [Presentation] 非定型的経過をたどった三叉神経痛の1例 (2014)
  • Author(s): 近藤美弥子
  • Organizer: 日本歯科心身医学会
  • Place of Presentation: 神奈川歯科大学横浜クリニック（神奈川県 横浜市）
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] ロフラゼプ酸エチルが奏効した高齢者味覚障害の2 例 (2014)
  • Author(s): 近藤美弥子
  • Organizer: 日本老年歯科医学会
  • Place of Presentation: 電気ビルみらいホール（福岡県 福岡市）
  • Year and Date: 2014-06-13 – 2014-06-14