Research for treating or preventing pneumococcal pneumonia
| Project/Area Number |
26861570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺炎球菌 / 好中球 / エラスターゼ / 免疫回避 / 補体 / Toll様受容体 |
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| Outline of Final Research Achievements |
Streptococcus pneumoniae is a Gram-positive bacterium that is a leading cause of bacterial pneumonia. It was suggested that excessively activated neutrophils release proteinases such as elastase that contribute to lung injury in severe pneumonia. However, underlying mechanisms are not fully understood. In this study, we investigated the effects of pneumococcal pneumolysin against neutrophils. Our findings suggest that S. pneumoniae induce neutrophil cell death caused by pneumococcal autolysis and subsequent release of pneumolysin and may trigger neutrophil elastase-dependent lung injury.
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Report
(3 results)
Research Products
(22 results)
