• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research for treating or preventing pneumococcal pneumonia

Research Project

Project/Area Number 26861570
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

DOMON Hisanori  新潟大学, 医歯学系, 助教 (00594350)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺炎球菌 / 好中球 / エラスターゼ / 免疫回避 / 補体 / Toll様受容体
Outline of Final Research Achievements

Streptococcus pneumoniae is a Gram-positive bacterium that is a leading cause of bacterial pneumonia. It was suggested that excessively activated neutrophils release proteinases such as elastase that contribute to lung injury in severe pneumonia. However, underlying mechanisms are not fully understood. In this study, we investigated the effects of pneumococcal pneumolysin against neutrophils. Our findings suggest that S. pneumoniae induce neutrophil cell death caused by pneumococcal autolysis and subsequent release of pneumolysin and may trigger neutrophil elastase-dependent lung injury.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans,2016

    • Author(s)
      Sakaue, Y.; Domon, H.; Oda, M.; Takenaka, S.; Kubo, M.; Fukuyama, Y.; Okiji, T.; Terao, Y.
    • Journal Title

      Microbiol. Immunol.

      Volume: 60 Issue: 1 Pages: 10-16

    • DOI

      10.1111/1348-0421.12343

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces.2016

    • Author(s)
      Domon H, Uehara Y, Oda M, Seo H, Kubota N, Terao Y.
    • Journal Title

      Microbiologyopen

      Volume: 5 Issue: 1 Pages: 39-46

    • DOI

      10.1002/mbo3.308

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells.2016

    • Author(s)
      Kurosawa M, Oda M, Domon H, Saitoh I, Hayasaki H, Terao Y.
    • Journal Title

      Microbes Infect.

      Volume: 18 Issue: 2 Pages: 118-127

    • DOI

      10.1016/j.micinf.2015.10.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tetranorsesquiterpenoids and Santalane-Type Sesquiterpenoids from Illicium lanceolatum and Their Antimicrobial Activity against the Oral Pathogen Porphyromonas gingivalis.2015

    • Author(s)
      Kubo, M.; Nishikawa, Y.; Harada, K.; Oda, M.; Huang, J.-M.; Domon, H.; Terao, Y.; Fukuyama, Y.
    • Journal Title

      J. Nat. Prod.

      Volume: 78 Issue: 6 Pages: 1466-1469

    • DOI

      10.1021/acs.jnatprod.5b00237

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice.2015

    • Author(s)
      Yamada H, Nakajima T, Domon H, Honda T, Yamazaki K
    • Journal Title

      J Periodontal Res.

      Volume: 未定 Issue: 4 Pages: 1-1

    • DOI

      10.1111/jre.12232

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis.2014

    • Author(s)
      Domon H, Tabeta K, Nakajima T, Yamazaki K.
    • Journal Title

      J Periodontal Res.

      Volume: (印刷中) Issue: 4 Pages: 536-543

    • DOI

      10.1111/jre.12134

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺炎球菌による肺組織傷害誘導メカニズムの解析2016

    • Author(s)
      土門 久哲,坂上 雄樹,小田 真隆,山口 雅也,川端 重忠,寺尾 豊
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenesの咽頭上皮細胞株への付着・侵入におけるCAMP factorの役割2016

    • Author(s)
      黒澤 美絵,小田 真隆,土門 久哲,寺尾 豊
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多機能性糖脂質によるマクロファージ細胞外捕獲網形成機構の解明2016

    • Author(s)
      小田 真隆,黒澤 美絵,土門 久哲,寺尾 豊
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺炎球菌による宿主細胞の細胞死誘導能の解析2015

    • Author(s)
      土門 久哲,坂上 雄樹,小田 真隆,山口 雅也,川端 重忠,寺尾 豊
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多機能性糖脂質によるマクロファージMETs形成メカニズムの解析2015

    • Author(s)
      小田 真隆,黒澤 美絵,土門 久哲,寺尾 豊
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenes CAMP factorのRAW264.7細胞に対する空胞形成メカニズムの検討2015

    • Author(s)
      黒澤 美絵,小田 真隆,土門 久哲,斎藤 一誠,早崎 治明,寺尾 豊
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenes CAMP factorのRAW264.7細胞に対する病原性解析2015

    • Author(s)
      黒澤美絵,小田真隆,土門久哲,寺尾豊
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Streptococcus mutansバイオフィルムに対する植物由来抽出物の検索2014

    • Author(s)
      坂上雄樹,土門久哲,小田真隆,興地隆史,寺尾豊
    • Organizer
      第51回日本細菌学会中部支部総会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Streptococcous pyogenes CAMP factorの免疫担当細胞に対する病原性解析2014

    • Author(s)
      黒澤美絵,小田真隆,土門久哲,寺尾 豊
    • Organizer
      第51回日本細菌学会中部支部総会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 多機能性糖脂質の自然免疫活性化メカニズムの解明2014

    • Author(s)
      小田真隆,山本博文,黒澤美絵,土門久哲,寺尾 豊
    • Organizer
      第51回日本細菌学会中部支部総会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 慢性炎症性疾患におけるT L R シグナル抑制因子の解析2014

    • Author(s)
      土門久哲,坂上雄樹,小田真隆,寺尾豊
    • Organizer
      第51回日本細菌学会中部支部総会
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] A群レンサ球菌CAMPファクターのマクロファージに対する病原性解析2014

    • Author(s)
      小田真隆,黒澤美絵,土門久哲,寺尾豊
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周炎におけるTLR シグナル抑制因子の解析2014

    • Author(s)
      土門久哲,小田真隆,寺尾豊
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 合成糖脂質のStreptococcus mutansバイオフィルムに対する作用2014

    • Author(s)
      黒澤美絵,小田真隆,土門久哲,寺尾豊
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Streptococcus mutansに対する植物由来抽出物の殺菌ならびに抗バイオフィルム効果の検討2014

    • Author(s)
      坂上雄樹,土門久哲,小田真隆,興地隆史,寺尾豊
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 新潟大学 大学院医歯学総合研究科 微生物感染症学分野

    • URL

      http://www.dent.niigata-u.ac.jp/microbio/microbio.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi