| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Streptococcus pneumoniae is a Gram-positive bacterium that is a leading cause of bacterial pneumonia. It was suggested that excessively activated neutrophils release proteinases such as elastase that contribute to lung injury in severe pneumonia. However, underlying mechanisms are not fully understood. In this study, we investigated the effects of pneumococcal pneumolysin against neutrophils. Our findings suggest that S. pneumoniae induce neutrophil cell death caused by pneumococcal autolysis and subsequent release of pneumolysin and may trigger neutrophil elastase-dependent lung injury.
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