| Project/Area Number |
26861571
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
|
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| Research Institution | Nara Medical University (2015-2017)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | BNCT / BPA / 5-FU / ICP / 細胞周期 / ホウ素中性子捕捉療法 / 化学療法 / CDDP / 移植系動物実験 / 放射線生物学 / 口腔がん |
|---|
| Outline of Final Research Achievements |
With neutron radiation after using boron pharmaceuticals（BPA) or X-ray, we collected foundational data, such as the survival rate curve. The relative biological effectiveness (RBE) from the survival rate curve to D10 was from approximately 2.5 to 3.0. Additionally, when we analyzed fluctuations in the cell cycles after irradiation, when isodose 2Gy irradiation was performed, in the neutron radiation group, it was recognized that the cell cycle stopped in the G2/M.
Next, with the transplantation-based animal experiments, an attempt was made to elucidate what cause existing BPA to accumulate in the tumor, and factors to prevent such accumulation. No significant difference was noted in the normal tissue of either group, but in the group to which 5-FU was administered to cancer tissue and 3 days later BPA was administered, a significant decrease in the absorption of boron was recognized.
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