| Project/Area Number |
26861572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射線治療 / 頭頸部癌 / IMRT / 口腔乾燥症 |
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| Outline of Final Research Achievements |
CT and MRI were performed in head and neck cancer patients treated with radiation therapy (RT) before RT, at 30 Gy during RT and one month after RT. Each major salivary gland volume, CT value and contrast enhanced ratio on the CT images and signal change rate on the T1 weighted MR images, the T2 weighted MR images and the diffusion weighted MR images were calculated. As a result, temporal decrease of the volumes and the CT values, the increase of the contrast enhanced ratios, the signal decrease on the T1 weighted images, the signal increase on the T2 weighted images, and the increase of the ADC (apparent diffusion coefficient) value on the diffusion weighted images were shown. An objective image assessment method for xerostomia induced by RT might be able to establish because some association were found between these imaging parameters and saliva flow.
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