The role of gingipains from P. gingivalis on host cell responses
| Project/Area Number |
26861573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周病原細菌 / ジンジパイン / 細胞内シグナル伝達 / PI3K/Akt経路 / 病原因子 / PI3K/Akt / PI3 kinase/Akt |
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| Outline of Final Research Achievements |
Peridontal diseases are chronic oral bacterial infectious diseases which indicate inflammation of periodontal tissues, alveolar bone loss, and, leading to loss of tooth. In this research, Porphyromonas gingivalis, which is one of the most major oral pathogens, produces cysteine proteases called as gingipains. The gingipains attenuate PI3 kinase/Akt signaling pathway, and Akt downstream proteins, which are mTOR, GSK3, Bad, PRAS40, and MDM2, are also altered the their level of phosphorylation by gingipains in gingival epithelial cells. Taken together, their activity is disturbed by gingipains in parallel with inactivation of PI3K/Akt.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis.2015
Author(s)
Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S, Ohara N.
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Journal Title
Infection and Immunity
Volume: 84
Issue: 1
Pages: 230-40
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis2015
Author(s)
Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, Hasegawa H
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Journal Title
BMC Oral Health
Volume: 15
Issue: 1
Pages: 4-4
DOI
Related Report
Peer Reviewed / Open Access
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