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The role of gingipains from P. gingivalis on host cell responses

Research Project

Project/Area Number 26861573
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOkayama University

Principal Investigator

Nakayama Masaaki  岡山大学, 医歯薬学総合研究科, 助教 (10579105)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯周病原細菌 / ジンジパイン / 細胞内シグナル伝達 / PI3K/Akt経路 / 病原因子 / PI3K/Akt / PI3 kinase/Akt
Outline of Final Research Achievements

Peridontal diseases are chronic oral bacterial infectious diseases which indicate inflammation of periodontal tissues, alveolar bone loss, and, leading to loss of tooth. In this research, Porphyromonas gingivalis, which is one of the most major oral pathogens, produces cysteine proteases called as gingipains. The gingipains attenuate PI3 kinase/Akt signaling pathway, and Akt downstream proteins, which are mTOR, GSK3, Bad, PRAS40, and MDM2, are also altered the their level of phosphorylation by gingipains in gingival epithelial cells. Taken together, their activity is disturbed by gingipains in parallel with inactivation of PI3K/Akt.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis.2015

    • Author(s)
      Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S, Ohara N.
    • Journal Title

      Infection and Immunity

      Volume: 84 Issue: 1 Pages: 230-40

    • DOI

      10.1128/iai.01308-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis2015

    • Author(s)
      Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, Hasegawa H
    • Journal Title

      BMC Oral Health

      Volume: 15 Issue: 1 Pages: 4-4

    • DOI

      10.1186/1472-6831-15-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuation of the PI3 kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.2015

    • Author(s)
      Nakayama M, Inoue T, Naito M, Nakayama K and Ohara N.
    • Journal Title

      J Biol Chem.

      Volume: 290 Pages: 5190-5202

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 33277.2015

    • Author(s)
      Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T, Ohara N.
    • Journal Title

      New Microbiologica.

      Volume: 38 Pages: 97-103

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 332772015

    • Author(s)
      Tetsuyoshi Inoue, Masaaki Nakayama, Yuko Taguchi, Konami Kano, Miyuu Ono, Yurika Shimizu, Teruo Kuroda, Naoya Ohara
    • Journal Title

      New Microbiologica

      Volume: 38 Pages: 97-103

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Porphyromonas gingivalis Gingipains RgpA, RgpB, and Kgp2015

    • Author(s)
      Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N
    • Journal Title

      Journal of Biological Chemistry

      Volume: 290 Issue: 8 Pages: 5190-5202

    • DOI

      10.1074/jbc.m114.591610

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a novel plasmid vector pTIO-1 adapted for electrotransformation of Porphyromonas gingivalis.2014

    • Author(s)
      Tagawa J, Inoue T, Naito M, Sato K, Kuwahara T, Nakayama M, Nakayama K, Yamashiro T, Ohara N.
    • Journal Title

      J Microbiol Methods

      Volume: 105 Pages: 174-179

    • DOI

      10.1016/j.mimet.2014.07.032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Porphyromonas gingivalis ジンジパインによるPGE2産生の分子機序2017

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第90回日本細菌学会総会 ポスター発表
    • Place of Presentation
      仙台国際センター展示棟
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯周病における P. gingivalis ジンジパインの重要性2017

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第90回日本細菌学会総会 シンポジウム口頭発表
    • Place of Presentation
      仙台国際センター展示棟
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] P. gingivalis ジンジパインの宿主細胞応答を介した病原性機能解析2016

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第69回日本細菌学会中国・四国支部総会-若手研究者奨励賞受賞記念講演
    • Place of Presentation
      かがわ国際会議場
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] PI3K/Akt 経路に対するP. gingivalis ジンジパインの役割2016

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第58回歯科基礎医学会学術大会 ポスター発表
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポルフィロモナス・ジンジバリスが産生するジンジパインによるPI3キナーゼ/Akt経路抑制の分子機序2016

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第58回歯科基礎医学会学術大会-第28回歯科基礎医学会学術奨励賞受賞講演・微生物学部門
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] P. gingivalis ジンジパインによるPI3K/Akt経路撹乱の分子解析2016

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪・大阪国際交流センター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] P. gingivalis ジンジパインによるPI3K/Akt経路撹乱の分子解析2015

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第68回日本細菌学会中国・四国支部総会
    • Place of Presentation
      岡山・岡山大学鹿田キャンパス 地域医療人育成センターおかやま (MUSCAT CUBE)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] P. gingivalisジンジパインによるPI3K/Akt経路の抑制効果とその意義2015

    • Author(s)
      中山 真彰, 内藤 真理子, 中山 浩次, 大原 直也
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟・朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯周病原細菌の感染による免疫応答と破骨細胞分化制御の相関性2015

    • Author(s)
      ○中山 真彰, 中山 浩次, 大原 直也
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] TLR2/MyD88経路を介した抗酸菌による破骨細胞分化制御2015

    • Author(s)
      ○中山 真彰, 中山 浩次, 瀧井 猛将, 大原 直也
    • Organizer
      第85回実験結核研究会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 細菌感染によるTLR2を介した破骨細胞分化制御とその意義2014

    • Author(s)
      ○中山 真彰, 井上哲圭, 中山 浩次, 大原 直也
    • Organizer
      第67回日本細菌学会中国・四国支部総会
    • Place of Presentation
      徳島文理大学 13 号館4 階大講義室 (徳島)
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 細菌感染による免疫応答が破骨細胞分化に与える影響2014

    • Author(s)
      ○中山 真彰, 井上哲圭, 中山 浩次, 大原 直也
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Book] 生物学に関する試験研究論叢「歯周病原細菌によるPI3K/Akt経路抑制機構の解明と感染における生理的意義」2015

    • Author(s)
      中山真彰
    • Total Pages
      294
    • Publisher
      財団法人両備てい園記念財団
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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