Development of combination theray with hyperthermia and targeted therapy for clinical application.
| Project/Area Number |
26861575
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 温熱療法 / 分子標的薬 / 口腔癌 / 併用療法 |
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| Outline of Final Research Achievements |
Our objective is whether combination therapy with hyperthermia and IL13-PE, targeted therapy could be useful for clinical application of oral cancer, in safty and more efficient for antitumor activity. We expected that combination therapy could modulate the expression of IL-13Ra2 and increase their sensitivity to IL13-PE, and then synergistic effects were observed in vivo study as translational research.
In our results, Tunel assay showed that combination therapy with hyperthermia and IL13-PE induced apoptotic cells in both HSC-3 and SCC-25 cell lines compared to control groups, significantly.
In vivo study showed that combination therapy with hyperthermia and IL13-PE reduced the tumor growth compared to the control mice.
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Report
(4 results)
Research Products
(8 results)
