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Clarification of the pathology of BRONJ and establishment of a new treatment method

Research Project

Project/Area Number 26861577
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKyushu Dental College

Principal Investigator

YOSHIGA Daigo  九州歯科大学, 歯学部, 准教授 (10507784)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords免疫 / 骨粗鬆症 / BRONJ / テリパラチド / ARONJ / MRONJ / モデルラット / bisphosphonate / teriparatide
Outline of Final Research Achievements

Osteonecrosis of the jaw is a major complication in patients using bisphosphonate agents for bone lesions. Osteonecrosis was induced by intraperitoneal administration of zoledronic acid (ZOL). TPTD administration reduced necrotic bone area of the mandibles and femurs in the BRON rat model and induced new bone formation. In addition, TPTD injection increased the number of osteoclasts. In conclusion, the nitrogen-containing bisphosphonate (NBP) ZOL has negative effects on osteoclasts. TPTD was found to be effective in eliminating the negative effects of NBPs. TPTD had positive effects in preventing bone resorption and promoting osteogenesis. In addition, TPTD improved osteoclastogenesis, which in turn led to the improvement of BRON. These results demonstrate the effects of TPTD on the biomechanical properties of the bone in a BRON rat model. Taken together, we suggest that intermittent administration of TPTD could be an effective treatment for BRON of the jaw (BRONJ).

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways2017

    • Author(s)
      Taketomi Takaharu、Onimura Tomohiro、Yoshiga Daigo、Muratsu Daichi、Sanui Terukazu、Fukuda Takao、Kusukawa Jingo、Nakamura Seiji
    • Journal Title

      Cell Biology International

      Volume: 9999 Issue: 9 Pages: 1-9

    • DOI

      10.1002/cbin.10876

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential role of mitogen-activated protein kinases in IL-17A-induced MMP-3 expression in human synovial sarcoma cells2016

    • Author(s)
      Sakurai T, Yoshiga D, Ariyoshi W, Okinaga T, Kiyomiya H, Furuta J, Yoshioka I, Tominaga K, Nishihara T
    • Journal Title

      BMC Res Notes

      Volume: 9 (1) Issue: 1 Pages: 68-68

    • DOI

      10.1186/s13104-016-1892-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An osteonecrosis model induced by oral bisphosphonate in ovariectomised rats.2015

    • Author(s)
      4)Tanaka J, Kokuryou S, Yoshiga D, Tsurushima H, Sakaguchi O,Habu M, Nishihara T, Yoshioka I, Tominaga K.
    • Journal Title

      Oral Disease

      Volume: 21 Issue: 8 Pages: 969-76

    • DOI

      10.1111/odi.12368

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraoperative detection of viable bone with fluorescence imaging using visually enhanced lesion scope in patients with bisphosphonate-related osteonecrosis of the jaw: clinical and pathological evaluation.2015

    • Author(s)
      Yoshiga D, Sasaguri M, Matsuo K, Kokuryou S, Habu M, Oda M, Kodama M, Tsurushima H, Sakaguchi O, Sakurai T, Tanaka J, Morimoto Y, Yoshioka I, Tominaga K.
    • Journal Title

      Osteoporos Int

      Volume: 26 Issue: 7 Pages: 1997-2006

    • DOI

      10.1007/s00198-015-3096-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intraoperative detection of viable bone with fluorescence imaging using Visually Enhanced Lesion Scope in patients with bisphosphonate-related osteonecrosis of the jaw: clinical and pathological evaluation2015

    • Author(s)
      Yoshiga D, Sasaguri M, Matsuo K, Kokuryou S, Habu M, Oda M, Kodama M, Tsurushima H, Sakaguchi O, Sakurai T, Tanaka J, Morimoto Y, Yoshioka I, and Tominaga K
    • Journal Title

      Osteoporos International

      Volume: Epub ahead of print

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation.2015

    • Author(s)
      Maruse Y, Kawano S, Kiyoshima T, Goto Y, Matsubara R, Chikui T, Yoshiga D, Nakamura S.
    • Journal Title

      Head and Neck

      Volume: 印刷中 Issue: 11 Pages: E161-E164

    • DOI

      10.1002/hed.24036

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] BRONJ モデルラットに おける遺伝子組み換えヒト副甲状腺ホルモン(Teriparatide)による治療効果に関する研究2018

    • Author(s)
      吉賀大午
    • Organizer
      第27回日本有病者歯科医療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨吸収抑制剤関連顎骨壊死(ARONJ)に対するテリパラチドの治療効果に関する 多施設共同後ろ向き観察研究2018

    • Author(s)
      森下廣太
    • Organizer
      第72回日本口腔科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MRONJ モデルラットを用いた MRONJ への Teriparatide の治療効果に関する研究2017

    • Author(s)
      池田浩之 吉賀大午 鶴島弘基 坂口修 田中純平 梶田倫功 土生学 笹栗正明 吉岡泉 冨永和宏
    • Organizer
      第71回日本口腔科学会総会
    • Place of Presentation
      松山
    • Year and Date
      2017-04-28
    • Related Report
      2016 Research-status Report
  • [Presentation] MRONJ モデルラットを用いた MRONJ への Teriparatide の治療効果に関する研究2017

    • Author(s)
      池田浩之
    • Organizer
      第71回日本口腔科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] :M1 マクロファージ分化誘導モデルにおけるビスフォスフォネートの影響2017

    • Author(s)
      金子純也
    • Organizer
      第71回日本口腔科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] BRONJモデルラットにおけるTeriparatideを用いた治療効果に関する研究2016

    • Author(s)
      池田浩之1 吉賀大午1 鶴島弘基2 坂口 修2 田中純平2  梶田倫功1 笹栗正明1 吉岡 泉2 冨永和宏1
    • Organizer
      第61回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨粗鬆症患者に発生した難治性BRONJに対するテリパラチド投与の臨床的検討2015

    • Author(s)
      吉賀大午 國領真也 喜多涼介 吉岡 泉 冨永和宏
    • Organizer
      第24回日本有病者歯科医療学会総会
    • Place of Presentation
      旭川
    • Year and Date
      2015-03-20 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] VELscopeRを用いた骨蛍光標識法によるBRONJ外科的治療時の切除域判定法2014

    • Author(s)
      吉賀大午 土生学 児玉正明 上原雅隆 笹栗正明 冨永和宏
    • Organizer
      第59回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2021-01-27  

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