Construction of new diagnostic and elucidation of the NASH pathogenesis mechanism by saliva metabolome analysis
| Project/Area Number |
26861582
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Saruta Juri 神奈川歯科大学, 歯学研究科(研究院), 准教授 (30454151)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 唾液 / メタボローム解析 / NASH / 生活習慣病 / マーカー探索 |
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| Outline of Final Research Achievements |
We have conducted the creation of NASH using rat model of obesity, diabetes, hyperlipidemia and hypertension. The saliva of these model rats were collected, it was carried out the measurement of the metabolite of saliva from the metabolome analysis.
From saliva analysis of four kinds model rat, among the detected 486 kinds of metabolites, significant differences between the model rats and control rats was observed 38 materials.
It determined the applied substance to the analysis of human in the metabolites identified in the results of model rats, and proceeded research for the application to humans.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Relationship between brain-derived neurotrophic factor and stress in saliva and salivary glands2014
Author(s)
Saruta Juri, To Masahiro, Hayashi Takashi, Kawashima Rie, Shimizu Tomoko, Kamata Yohei, Kato Momoko, Takeuchi Mifumi, Tsukinoki Keiichi
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 26
Issue: 3
Pages: 379-389
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of weekly one-hour hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders: A randomized controlled eight-week trial.2015
Author(s)
Ikai Saeko, Suzuki Takefumi, Saruta Juri, Tsukinoki Keiichi, Kitahata Ryosuke, Tani Hideki, Nagai Nobuhiro, Endo Aki, Otani Ai, Mimura Masaru, Fujii Yasuo, Uchida Hiroyuki
Organizer
15th International Congress on Schizophrenia Research
Place of Presentation
Colorado Springs, Colorado, USA
Year and Date
2015-03-28 – 2015-04-01
Related Report
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[Presentation] Relationship of sleep bruxism and migraine.2014
Author(s)
Kato Momoko, Saruta Juri, Takeuchi Mifumi, Igarashi Hisaka, Kawata Toshitsugu, Tsukinoki Keiichi
Organizer
4th European Headache and Migraine Trust International Congress
Place of Presentation
Copenhagen, Denmark
Year and Date
2014-09-18 – 2014-09-24
Related Report
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[Presentation] Effect of occlussal sprint in migraine patients.2014
Author(s)
Takeuchi Mifumi, Saruta Juri, Kato Momoko, Igarashi Hisaka, Kawata Toshitsugu, Tsukinoki Keiichi
Organizer
4th European Headache and Migraine Trust International Congress
Place of Presentation
Copenhagen, Denmark
Year and Date
2014-09-18 – 2014-09-24
Related Report
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