Assesment of creation and leading of remineralization of artificial caries affected dentin using Fluoride and Calcium containing materials

• Project/Area Number: 26861590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INOUE GO 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40431928)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: FCP-COMPLEX / caries affected dentin / remineralization / fluoride / 耐酸性の向上 / 歯質強化 / う蝕象牙質内層 / フッ素 / カルシウム / カルシウム入りプライマー / ABRZ

Outline of Final Research Achievements

The application of Fluoride, Calcium and Phosphate containing solution, so-called FCP-COMPLEX or Sodium Fluoride solution had good effects on the dentin-adhesive interface, after making the artificial caries affected dentin model with bovine and human tooth. Especially FCP-COMPLEX solution could penetrate into deeper area of the artificial caries affetced dentin than normal dentin, and could resist the secondary acid attack at the surface. These results were observed by SEM. Also a creation of CaF on the superfacial layer could be detected by using XAFS, but it was in conjecture that fluoroapatite could be created in deeper area.

Research Products

• [Journal Article] Dentin bonding performance and interface observation of an MMA-based restorative material (2016)
  • Author(s): Shinagawa J, Inoue G, Nikaido T, Tagami J
  • Journal Title: Dent Mater J Volume: 35 Issue: 4 Pages: 578-584
  • DOI: 10.4012/dmj.2015-363
  • NAID: 130005254749
  • Peer Reviewed
• [Presentation] Influence of FCP-COMPLEX on bond strength to caries-affected dentin (2016)
  • Author(s): Atomura J, Inoue G, Ikeda M, Nikaido T, Tagami J
  • Organizer: 94th International Association for Dental Research
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] Surface assessment on artificial caries-affected dentin with FCP-COMPLEX (2016)
  • Author(s): G Inoue, R Mashiko, S Nakashima, J Tagami
  • Organizer: 45th American Association for Dental Rresearch
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] Morphological Assessment of the Effect of Calcium-containing Primer System (2015)
  • Author(s): Inoue G, Mashiko R, Atomura J, Tagami J
  • Organizer: 6th International for Adhesive Dentistry
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-01-31 – 2015-02-01