The analysis of dendritic cells in rat denatl pulp

Research Project

Project/Area Number	26861592
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Conservative dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Aramaki Oto 東京医科歯科大学, 歯学部附属病院, 医員 (60634615)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	歯髄 / 樹状細胞 / う蝕
Outline of Final Research Achievements	We confirmed that there existed the MHC classII and CD11c positive dendritic cells in rat normal dental pulp by immunohistochemistry. And we also showed the CD103-positive dendritic cells in rat normal dental pulp. It is suggested that adaptive immunity (mainly dendritic cells) may play an important role in dental pulp. We further showed that there are Iba1 positive cells which have ramifications in the front of human dental pulp by three-dimensional analysis. From our findings, there are many macrophages in the front of dental pulp which may induce adaptive immunity.

Report

(3 results)