Exploration of a TNF-alpha-nducing factor produced by pulp cells
| Project/Area Number |
26861596
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯髄細胞 / マクロファージ |
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| Outline of Final Research Achievements |
We focused on the protein which dental pulp fibroblasts secreted, and we identified TNF-α instruction factor of the macrophage so far. This time, the candidate molecules except the protein, in particular, focus on extracellular secretion nucleic acid, it has been promoting its identification. A large amount on the culture supernatant DNA and mRNA was concentrated and recovered a result of the action in THP-1, TNF-α production-inducing ability was the degree to which the presence slightly. The recovered nucleic acids, there is a possibility of increasing the TNF-α production inducing ability by interaction with the proteins produced from pulp cells, it is currently considering.
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Report
(3 results)
Research Products
(1 results)
