The effects of gene associated with sucrose phosphotransferase system on development of dental caries by Streptococcus mutans

• Project/Area Number: 26861597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KIMURA Tomoko 徳島大学, 大学病院, 助教 (20581367)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 歯学 / う蝕 / 細菌 / 遺伝子

Outline of Final Research Achievements

The aim of this study was to investigate the involvement of scrA gene deeply related to the acidogenic activity in cariogenic bacterium in the hydrophobicity and bacterial invasion into the dentinal tubules by Streptococcus mutans. As a result, scrA gene was shown to be not affect the hydrophobicity of the cell surface. The observation of the dentinal tubules demonstrated that scrA gene had an effect on the bacterial invasion into the dentinal tubules.