The identifications of Streptococcus mutans nobel virulence factors involved in systemic disease

• Project/Area Number: 26861601
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Kagoshima University
• Principal Investigator: FUJISHIMA KEI 鹿児島大学, 医歯学域 歯学系, 助教 (50553153)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 菌体表層タンパク

Outline of Final Research Achievements

Generally Streptococcus mutans(S. mutans) are known as pathogenic bacteria of teeth caries in dental area, but recently S. mutans are also featured as virulence factors to systemic disease. So we have focused on superficial proteins as virulence factors of S. mutans.In this validation, we report that sortase which localize proteins produced intracellular to membrane are involved in the ability of attachment to hela cells. And more there are six proteins which is dependent on sortase, we also report it is likely that wapA plays a crucial role in attachment to hela cells.