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Application of bioglass cement in the regeneration therapy of dental pulp and periapical tissue

Research Project

Project/Area Number 26861602
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Washio Ayako  九州歯科大学, 歯学部, 助教 (10582786)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオガラス / 歯科用セメント / ハイドロキシアパタイト / 生体親和性
Outline of Final Research Achievements

The final goal of this study is to establish the regeneration therapy of dentin and pulp complex and periapical tissue. To achieve the aim, I develop and investigate dental cement (NSY-222) combined "the bioglass" which is kind of biomedical materials.
NSY-222 had suitable properties as dental material. It was suggested that tag-like structure formed in NSY-222 provided good penetration, NSY-222 was removed from root canal, and NSY-222 have biocompatibility for pulp and apical periodontal tissue. In addition, it was suggested that NSY-222 had the inducibility of calcified tissue .

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of 4-META/MMA-TBB resin at different curing stages on osteoblasts and gingival epithelial cells.2016

    • Author(s)
      Morotomi T, Hirata-Tsuchiya S, Washio A, Kitamura C:
    • Journal Title

      Journal of Adhesive Dentistry

      Volume: 18 Pages: 111-118

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-rich plasma enhances the differentiation of dental pulp progenitor cells into odontoblasts2015

    • Author(s)
      Yeom K, Ariyoshi W, Okinaga T, Washio A, Morotomi T, Kitamura C, Nishihara T
    • Journal Title

      International Endodontic Journal

      Volume: in print Issue: 3 Pages: 271-278

    • DOI

      10.1111/iej.12443

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Physicochemical properties of newly developed bioactive glass cement and its effects on various cells.2014

    • Author(s)
      Washio A, Nakagawa A, Nishihara T, Maeda H, Kitamura C
    • Journal Title

      Journal of Biomedical Materials Research: Part B

      Volume: 103 Issue: 2 Pages: 373-380

    • DOI

      10.1002/jbm.b.33209

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 新規バイオガラス配合根管充填シーラーの根管封鎖性の検討2015

    • Author(s)
      吉居慎二,鷲尾絢子,諸冨孝彦,北村知昭
    • Organizer
      第143回日本歯科保存学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Platelet rich plasma induces differentiation of odontoblast-like cells.2015

    • Author(s)
      Yeom K, Ariyoshi W, Washio A, Kitamura C, Nishihara T
    • Organizer
      3nd Asian Pacific International Conference
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 象牙質・歯髄複合体の局所的再生誘導療法におけるゼラチン-バイオガラス複合スポンジの有効性の検討2015

    • Author(s)
      鷲尾絢子,田畑泰彦,北村知昭
    • Organizer
      第13回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ストロンチウム置換生体活性ガラスの象牙芽細胞分化誘導能を有するスキャホールド材としての可能性2015

    • Author(s)
      諸冨孝彦,西藤法子,鷲尾絢子,北村知昭
    • Organizer
      第13回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規バイオガラス配合根管充填用シーラーの物理化学的特性と生物学的影響2015

    • Author(s)
      鷲尾絢子,吉居慎二,諸冨孝彦,北村知昭
    • Organizer
      第36回日本歯内療法学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規バイオガラス配合根管充填用シーラーの封鎖性と生物学的影響2015

    • Author(s)
      鷲尾絢子,吉居慎二,諸冨孝彦,北村知昭
    • Organizer
      第142回日本歯科保存学会学術大会
    • Place of Presentation
      北九州
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規バイオガラス配合根管充填用シーラーの各種細胞に及ぼす影響2015

    • Author(s)
      鷲尾絢子,吉居慎二,諸冨孝彦,北村知昭
    • Organizer
      第75回九州歯科学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 象牙質・歯髄複合体の再生誘導療法におけるゼラチン-バイオガラス複合スポンジの有効性の検討2015

    • Author(s)
      鷲尾絢子,北村知昭,田畑泰彦
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of Gelatin and Bioglass Sponge Composites Capable of Fibroblast Growth Factor 2 Release for Dentin and Pulp Regeneration.2015

    • Author(s)
      Washio A, Kitamura C
    • Organizer
      The Asia Pacific Conference in Fukuoka 2015
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2015-01-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 象牙質・歯髄複合体形成におけるゼラチン-バイオガラス複合スポンジの有効性の検討2014

    • Author(s)
      鷲尾絢子,北村知昭,田畑泰彦
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Preparation of gelatin and bioglass sponge composites capable of fibroblast growth factor 2 release for dentin and pulp regeneration.2014

    • Author(s)
      Washio A, Tabata Y, Kitamura C
    • Organizer
      The 41st International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 多血小板血漿が象牙芽細胞様細胞(KN-3細胞)に与える影響.2014

    • Author(s)
      廉 炅勲,鷲尾絢子,諸冨孝彦,永吉雅人,北村知昭
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 象牙質・歯髄複合体の再生誘導に用いるゼラチン-バイオガラス複合スポンジの検討.2014

    • Author(s)
      鷲尾絢子,田畑泰彦,北村知昭
    • Organizer
      第35回日本歯内療法学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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