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Establishment of the remineralization therapy that targeted root caries- application of Peptide P11-4

Research Project

Project/Area Number 26861608
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionNihon University

Principal Investigator

TAKIMOTO Masayuki  日本大学, 歯学部, 専修医 (90723239)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords根面齲蝕 / 脱灰抑制 / 再石灰化 / ペプチド / 光干渉断層画像法 / 超音波測定装置 / ペプチド(P11-4) / 超音波透過法
Outline of Final Research Achievements

This study evaluates the effect of self-assembling peptide P11-4 on bovine
dentin remineralization by measuring changes in ultrasonic propagation velocity and using opticalcoherence tomography. Sonic velocity was found to decrease with time for specimens stored in the demineralizing solution. On the other hand, increases in sonic velocity were found for specimens treated with P11-4 . By measuring the ultrasonic propagation velocity, it can be concluded that P11-4 application has an ability to promote bovine dentin remineralization.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization2016

    • Author(s)
      Fuminori Takahashi, Hiroyasu Kurokawa, Sho Shibasaki, Ryo Kawamoto, Ryosuke Murayama, Masashi Miyazaki
    • Journal Title

      Acta Odontologica Scandinavica

      Volume: 74 Pages: 142-147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Effect of Coating Material Containing S-PRG Filler on the Prevention of Enamel Demineralization Detected by Optical Coherence Tomography2014

    • Author(s)
      村山 良介, 松吉 佐季, 柴崎 翔, 土屋 賢司, 瀧本 正行, 川本 諒, 黒川 弘康, 宮崎 真至
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 57 Issue: 6 Pages: 578-588

    • DOI

      10.11471/shikahozon.57.578

    • NAID

      130005005962

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ペプチドP11-4のエナメル質への応用におけるOCT像の観察2015

    • Author(s)
      瀧本正行,高橋史典,黒川弘康,古市哲也,佐藤愛子,寺井里沙,宮崎真至
    • Organizer
      日本歯科保存学会平成27年度春季大会(第142回)
    • Place of Presentation
      北九州国際会議場(福岡県北九州市小倉北区)
    • Year and Date
      2015-06-25 – 2015-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 根面齲蝕をターゲットとした再石灰化療法の確立へのペプチドP11-4の応用2014

    • Author(s)
      高橋史典,黒川弘康,村山良介,瀧本正行,小泉美香,瀧川智義,佐藤幹武,宮崎真至
    • Organizer
      日本歯科保存学会平成26年度秋季大会(第141回)
    • Place of Presentation
      山形テルサ(山形県山形市双葉町)
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] ペプチド(P11-4)の応用がエナメル質再石灰化および脱灰抑制に及ぼす影響2014

    • Author(s)
      高橋史典,鈴木崇之,川本諒,岩佐美香,黒川弘康,宮崎真至
    • Organizer
      第66回日本大学歯学会総会・学術大会
    • Place of Presentation
      日本大学歯学部(東京都千代田区)
    • Year and Date
      2014-05-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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