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Elucidation of facilitatory effect and neuromuscular mechanism in swallowing function induced by pharyngeal electrical stimulation

Research Project

Project/Area Number 26861630
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNiigata University

Principal Investigator

MAGARA Jin  新潟大学, 医歯学総合病院, 講師 (90452060)

Research Collaborator Hamdy Shaheen  University of Manchester, Centre for Gastrointestinal Sciences
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords摂食嚥下障害 / リハビリテーション / 末梢感覚刺激 / 咽頭電気刺激 / 口腔感覚刺激 / 経頭蓋磁気刺激 / 運動誘発電位 / 嚥下障害 / 嚥下機能 / 化学刺激 / 神経可塑性変化 / 感覚刺激
Outline of Final Research Achievements

Previous works have showed that human pharyngeal motor cortical excitability can be induced by pharyngeal electrical stimulation (PES) and swallowing carbonated water (CW). This study is aimed to investigate whether synchronously combining PES with swallowing (of still water (SW) or CW) can potentiate this excitation in pharyngeal cortical area and brainstem. Transcranial magnetic stimulation (TMS) was used to take brain response.
Fourteen healthy volunteers participated and underwent the baseline brain response measurements with TMS. Subjects were then randomised to receive one of four 10-minute interventions (PES only, ShamPES+CW, PES+CW and PES+SW). Brain response were then remeasured for up to 60 minutes. In results, only PES alone was able to induce sustained changes in pharyngeal cortical excitability. Our data suggest that PES alone may be most advantageous in dysphagic patients who have a difficulty in performing voluntary swallows.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Int'l Joint Research] Centre for Gastrointestinal Sciences/University of Manchester(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Exploring the effects of synchronous pharyngeal electrical stimulation with swallowing carbonated water on cortical excitability in the human pharyngeal motor system2016

    • Author(s)
      Magara, J. Michou, E. Raginis-Zborowska, A. Inoue, M. Hamdy, S.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 28(9) Issue: 9 Pages: 1391-1400

    • DOI

      10.1111/nmo.12839

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 口腔内への温度刺激がもたらす咽頭皮質延髄路の変調2017

    • Author(s)
      真柄 仁,渡邊賢礼,酒井翔悟,鈴木 拓,辻村恭憲,井上 誠
    • Organizer
      第40回日本嚥下医学会総会並びに学術講演会
    • Place of Presentation
      学術総合センター・一橋講堂(東京都千代田区)
    • Year and Date
      2017-02-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effect of sensory stimulation on swallowing motor system - therapeutical strategy for dysphagic patients -2017

    • Author(s)
      Magara J, Inoue M
    • Organizer
      International Symposium on Development of Human Resources in Practical Oral Health and Treatment, Collaborative Symposium Faculty of Dentistry Prince of Songkla University - Niigata University
    • Place of Presentation
      Manathai Koh Samui, Koh Samui (Thailand)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between tongue pressure and pharyngeal residues in dysphagic patients2016

    • Author(s)
      Magara J, Tsuji K, Watanabe M, Tsujimura T, Hori K, Inoue M
    • Organizer
      6th European Society for Swallowing Disorders Congress
    • Place of Presentation
      Universita degli Studi Di Milano, Milan (Italy)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 疾患別に見た舌圧発現の特徴2016

    • Author(s)
      真柄 仁,辻 光順,林 宏和,辻村恭憲,堀 一浩.井上 誠
    • Organizer
      第39回日本嚥下医学会総会ならびに学術講演会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-02-12
    • Related Report
      2015 Research-status Report
  • [Presentation] The effect of combining pharyngeal electrical stimulation with simultaneous swallowing solutions on swallowing motor system.2016

    • Author(s)
      Magara J, Inoue M:
    • Organizer
      International collaborative symposium on development of human resources in practical oral health and treatment
    • Place of Presentation
      Lombok(Indonesia)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of synchronous pharyngeal electrical stimulation with swallowing carbonated water on the human pharyngeal motor system2016

    • Author(s)
      Magara J, Inoue M, Hamdy S
    • Organizer
      The Japanese Society of Dysphagia Rehabilitation, Japan-Korea Joint Symposium
    • Place of Presentation
      Toki Messe Niigata Convention Center (Niigata)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 嚥下関連神経ネットワークに対する末梢感覚刺激の併用効果2016

    • Author(s)
      真柄 仁,井上 誠
    • Organizer
      第7回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Exploring the effects of synchronous pharyngeal electrical stimulation and carbonated water on cortical excitability?2015

    • Author(s)
      Magara J, Michou E, Inoue M, Hamdy S
    • Organizer
      5th Congress of European Society for Swallowing Disorders
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 感覚刺激がもたらす嚥下機能の変化 「機能研究の未来創造 ~2050年の顎口腔機能研究~」2015

    • Author(s)
      真柄 仁
    • Organizer
      第54回日本顎口腔機能学会
    • Place of Presentation
      鹿児島大学 郡元キャンパス学習交流プラザ(鹿児島県鹿児島市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 咽頭電気刺激がもたらす嚥下関連機能の神経可塑性変化2014

    • Author(s)
      真柄 仁,谷口 裕重,林 宏和,竹石 龍右,辻村 恭憲,堀 一浩,井上 誠
    • Organizer
      第52回 日本顎口腔機能学会
    • Place of Presentation
      岡山大学歯学部
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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