Development of periodontal ligament-derived cell sheet

• Project/Area Number: 26861631
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Niigata University
• Principal Investigator: Kaku Sakiko 新潟大学, 医歯学総合病院, 医員 (60584589)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 歯根膜細胞 / コラーゲン翻訳後修飾 / 歯根膜

Outline of Final Research Achievements

In the present study, cyclic mechanical loading affect the gene expression of type I collagen and collagen-modifying enzymes on mouse periodontal ligament-derived cells. These results indicate that optimization of loading regimen may enhance the quantity and quality of type I collagen matrix produced by periodontal ligament-derived cells.