Effect of growth factors on endogenous cell recruitment and angiogenesis
| Project/Area Number |
26861632
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血管新生 / 細胞動員 / 細胞遊走 / 骨再生 / 幹細胞 |
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| Outline of Final Research Achievements |
In the present study, transplanted osteogenic cells did not differentiated into osteoblasts and matrix-embedded osteocytes. Interestingly, addition of SDF-1, a chemoattractant, significantly accelerated the bone formation in calvarial bony defect. These results indicate that acceleration of angiogenesis and mobilization of host-derived cells will be a promising approach for bone regeneration.
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Report
(3 results)
Research Products
(4 results)
