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Effect of growth factors on endogenous cell recruitment and angiogenesis

Research Project

Project/Area Number 26861632
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNiigata University

Principal Investigator

Rosales Marcelo  新潟大学, 医歯学系, 助教 (20727127)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管新生 / 細胞動員 / 細胞遊走 / 骨再生 / 幹細胞
Outline of Final Research Achievements

In the present study, transplanted osteogenic cells did not differentiated into osteoblasts and matrix-embedded osteocytes. Interestingly, addition of SDF-1, a chemoattractant, significantly accelerated the bone formation in calvarial bony defect. These results indicate that acceleration of angiogenesis and mobilization of host-derived cells will be a promising approach for bone regeneration.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (1 results)

  • [Int'l Joint Research] University of North Carolina(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Prolonged Survival of Transplanted Osteoblastic Cells Does Not Directly Accelerate the Healing of Calvarial Bone Defects.2016

    • Author(s)
      Kitami M, Kaku M, Rocabado JM, Ida T, Akiba N, Uoshima K.
    • Journal Title

      J Cell Physiol.

      Volume: 232 Issue: 9 Pages: 1974-82

    • DOI

      10.1002/jcp.25302

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament.2015

    • Author(s)
      Kaku M, Rosales Rocabado JM, Kitami M, Ida T, Akiba Y, Yamauchi M, Uoshima K.
    • Journal Title

      J Cell Physiol.

      Volume: 231(4) Issue: 4 Pages: 926-933

    • DOI

      10.1002/jcp.25184

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 歯根膜には大腿骨骨髄に由来する幹細胞が存在する2014

    • Author(s)
      加来 賢, 北見恩美, JM Rosales, 井田貴子, 秋葉陽介, 魚島勝美
    • Organizer
      第123回日本補綴歯科学会
    • Place of Presentation
      仙台、仙台国際センター
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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