Vertical Bone Augmentation Using iPS Cell Constructs with small molecule

• Project/Area Number: 26861634
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Kayashima Hiroki 大阪大学, 歯学研究科(研究院), 助教 (50632121)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 再生医療 / バイオロジー

Outline of Final Research Achievements

Small molecules such as simvastatin can enhance osteogenesis of iPS cells and promote mature bone formation of iPS cells. Therefore, small molecules could be promising for investigating the basis of osteogenic differentiation of iPS cells for future bone tissue engineering to achieve successful results of dental implant and prosthetic treatments.

Research Products

• [Journal Article] Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation in vitro. (2014)
  • Author(s): Egusa, H., Kayashima, H., Miura, J., Uraguchi, S., Wang, F., Okawa, H., Sasaki, J.I., Saeki, M., Matsumoto, T., and Yatani, H.
  • Journal Title: Stem cells and development. Volume: 23 Issue: 18 Pages: 2156-2169
  • DOI: 10.1089/scd.2013.0344
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] iPS細胞を用いたスキャフォールドフリー骨増生技術の開発 (2015)
  • Author(s): 大川博子，萱島浩輝，佐々木淳一，矢谷博文，江草宏
  • Organizer: 第45回 公益社団法人日本口腔インプラント学会学術大会
  • Place of Presentation: グランヴィア岡山（岡山県，岡山市）
  • Year and Date: 2015-09-21
• [Presentation] Vertical bone augmentation using iPS cell constructs with Simvastatin (2014)
  • Author(s): Okawa H, Kayashima H, Yamamoto H, Yatani H, Egusa H
  • Organizer: The 9th Biennial Congress of Asian Academy of Prosthodontics
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-11-22 – 2014-11-24
• [Presentation] Fabrication of Biomimetic Bone Graft Materials Using iPS Cells (2014)
  • Author(s): Yamamoto H, Okawa H, Kayashima H, Yamamoto H, Yatani H, Egusa H
  • Organizer: The 9th Biennial Congress of Asian Academy of Prosthodontics
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-11-22 – 2014-11-24
• [Presentation] スタチン化合物がiPS細胞の骨芽細胞分化に及ぼす影響 (2014)
  • Author(s): 大川博子，萱島浩輝，矢谷博文，江草 宏
  • Organizer: 平成26年度日本補綴歯科学会 中国・四国・関西支部合同支部学術大会
  • Place of Presentation: 倉敷, 岡山
  • Year and Date: 2014-09-07 – 2014-09-08
• [Presentation] Vertical bone augmentation using iPS cell constructs with Simvastatin (2014)
  • Author(s): Okawa H, Kayashima H, Yamamoto H, Yatani H, Egusa H.
  • Organizer: 92th IADR General Session
  • Place of Presentation: Capetown, South Africa
  • Year and Date: 2014-06-27 – 2014-06-30